A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
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Summary
The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
- Type
- article
- Published
- 1997-07-24
- Cited by
- 6,087
- References
- 20
- Access
- Open access
- OpenAlex
- https://openalex.org/W1483162601
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4311321
Keywords
Toll, Drosophila (subgenus), Acquired immune system, Immunity, Cell biology
References
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- The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo.
- The Instructive Role of Innate Immunity in the Acquired Immune Response
- Issues in searching molecular sequence databases
- The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor.
- Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein.
- Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum.
- The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression.
- Molecular genetics of Drosophila immunity.
- Signals from the IL-1 receptor homolog, Toll, can activate an immune response in a Drosophila hemocyte cell line.
- A conserved signaling pathway: the Drosophila toll-dorsal pathway.
- Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
- Approaching the asymptote? Evolution and revolution in immunology.
- The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults.
- Ancient relationships
- Defining protective responses to pathogens: cytokine profiles in leprosy lesions.
Cited by
- Two receptor theory in innate immune activation: studies on the receptors for bacillus Culmet Guillen-cell wall skeleton.
- Wolbachia endosymbiont of Onchocerca volvulus: driver of immunopathology and target for therapy
- Liposomes:Formulation and characterisation as contrast agents and as vaccine delivery systems
- DISSECTING THE MECHANISM OF NLRP3 INFLAMMASOME ACTIVATION IN INDIVIDUAL CELLS: THE ROLE OF REACTIVE OXYGEN SPECIES AND ORGANELLE DAMAGE
- Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
- Innate immunity: Lipoproteins take their Toll on the host
- Toll-Like Receptors Confer Responsiveness to Lipopolysaccharide from Porphyromonas gingivalis in Human Gingival Fibroblasts
- Contemporary models for peripheral tolerance and the classical 'historical postulate'.
- Toll‐like receptors: molecular mechanisms of the mammalian immune response
- Cinderella goes to the ball
- Role of Toll-Like Receptors in Changes in Gene Expression and NF-κB Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide
- Evaluation of toll-like receptor 4 gene expression of immortalized human liver cell lines.
- Does activation of the innate immune system contribute to the development of rheumatoid arthritis?
- Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
- Toll-like receptor signaling in sepsis
- Toll-Like Receptor 4-Defective C3H/HeJ Mice Are Not More Susceptible than Other C3H Substrains to Infection with Mycobacterium tuberculosis
- The Urokinase Receptor Can Be Induced by Borrelia burgdorferi through Receptors of the Innate Immune System
- Injury, sepsis, and the regulation of Toll‐like receptor responses
- Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-κB and Interleukin-8 Expression
- Interferon-α in systemic lupus erythematosus
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