Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections
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Summary
Although the deletion of genes encoding PRRs or proinflammatory cytokines does not improve the mortality of mice infected with influenza A virus, a partial block of the innate immune response is successful in decreasing the mortality rate of mice without a loss of protection against virus infection.
- Type
- review
- Published
- 2017-07-01
- Cited by
- 52
- References
- 183
- OpenAlex
- https://openalex.org/W2625922832
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5005235
Keywords
Innate immune system, Pattern recognition receptor, Immunology, Proinflammatory cytokine, Biology
References
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- A Toll-like receptor recognizes bacterial DNA
- MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression
- DEAD/H BOX 3 (DDX3) helicase binds the RIG‐I adaptor IPS‐1 to up‐regulate IFN‐β‐inducing potential
- Characterization of murine lung interstitial macrophages in comparison with alveolar macrophages in vitro.
- INAM Plays a Critical Role in IFN-γ Production by NK Cells Interacting with Polyinosinic-Polycytidylic Acid–Stimulated Accessory Cells
- Increased Expression of IL-33 in Severe Asthma: Evidence of Expression by Airway Smooth Muscle Cells1
- Dendritic cells and the control of immunity
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- TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses1
- Pulmonary Pathologic Findings of Fatal 2009 Pandemic Influenza A/H1N1 Viral Infections
- 2009 Pandemic Influenza A (H1N1)
- Chemokine Receptor CCR2 but Not CCR5 or CCR6 Mediates the Increase in Pulmonary Dendritic Cells during Allergic Airway Inflammation1
- IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
- A Distinct Function of Regulatory T Cells in Tissue Protection
- The impact of bacterial and viral co‐infection in severe influenza
Cited by
- Integrated Lung and Tracheal mRNA-Seq and miRNA-Seq Analysis of Dogs with an Avian-Like H5N1 Canine Influenza Virus Infection
- TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
- Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment
- Programmed Cell Death in the Pathogenesis of Influenza
- Enhanced Production of Pro-IL-1Βeta Contributes to Immunopathology during the Coinfection of Influenza a Virus and Streptococcus Pneumoniae
- Chandipura virus changes cellular miRNome in human microglial cells
- What can we learn about influenza infection and vaccination from transcriptomics?
- Innate Immune Evasion by Human Respiratory RNA Viruses
- Toll-like receptor bioactivity in endothelial progenitor cells
- Targeting Host Innate and Adaptive Immunity to Achieve the Functional Cure of Chronic Hepatitis B
- Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens
- Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.
- Molecular cloning, functional characterization and expression analysis of P65 subunit in response to GCRV infection in rare minnow (Gobiocypris rarus).
- The role of medicinal products in the treatment of inflammatory bowel diseases (IBD) through inhibition of TLR4/NF‐kappaB pathway
- Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
- TBK1 regulates the induction of innate immune response against GCRV by phosphorylating IRF3 in rare minnow (Gobiocypris rarus).
- Circulating Levels of Interleukin-6 and Interleukin-10, But Not Tumor Necrosis Factor-Alpha, as Potential Biomarkers of Severity and Mortality for COVID-19: Systematic Review with Meta-analysis
- SARS-CoV-2: Immune Response Elicited by Infection and Development of Vaccines and Treatments
- An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responses
- Host innate immune responses of geese infected with goose origin nephrotic astrovirus.
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