Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense1
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Summary
The data suggest that TLR2 plays a limited role in the innate immune response to pneumococcal pneumonia, and that additional pattern recognition receptors likely are involved in host defense against this common respiratory pathogen.
- Type
- article
- Published
- 2004-03-01
- Cited by
- 175
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W1550704138
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6130366
Keywords
TLR2, Lipoteichoic acid, Streptococcus pneumoniae, Innate immune system, Immunology
References
- Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid fromStaphylococcus aureus
- In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation1
- A Toll-like receptor recognizes bacterial DNA
- Toll-like receptors and innate immunity
- The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
- Toll-like receptors in the induction of the innate immune response
- Management of community-acquired pneumonia in the era of pneumococcal resistance: a report from the Drug-Resistant Streptococcus pneumoniae Therapeutic Working Group.
- Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia.
- Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2*
- The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
- Treatment of community-acquired pneumonia--IDSA guidelines. Infectious Diseases Society of America.
- Toll-like receptors.
- Bacteremic and Nonbacteremic Pneumococcal Pneumonia A Prospective Study
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
- Cytokines in innate host defense in the lung.
- Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved*
- Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
- [Induction of direct antimicrobial activity through mammalian toll-like receptors].
- Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice.
- TNF-α Compensates for the Impaired Host Defense of IL-1 Type I Receptor-Deficient Mice During Pneumococcal Pneumonia1
Cited by
- Mannose-binding lectin genotype and invasive pneumococcal infection.
- High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia
- Functional assessment of Toll-like receptor 2 and its relevance in patients with Staphylococcus aureus infection of joint prosthesis.
- Inflammatory response to severe bacterial infections
- R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae
- The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts.
- Characterization of host and microbe interactions affecting adherence, clearance and systemic spread of S. pneumoniae
- Interplay of virulence factors in complement resistance of Streptococcus pneumoniae
- TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis
- Platelet-Activating Factor Receptor Contributes to Host Defense against Pseudomonas aeruginosa Pneumonia but Is Not Essential for the Accompanying Inflammatory and Procoagulant Response1
- Prise en charge des pneumonies graves à pneumocoque — Pneumonies communautaires aiguës sévères à Streptococcus pneumoniae (PAC Sp): rôle de l’hôte et des facteurs de virulence bactérienne
- Toll-like receptors and innate immunity in pneumonia
- Lipoteichoic Acid-Induced Lung Inflammation Depends on TLR2 and the Concerted Action of TLR4 and the Platelet-Activating Factor Receptor
- Characterisation of Treg and Th17 cells in nasopharynx-associated lymphoid tissue and their association with pneumococcal carriage in children and adults
- Recognition and clearance of Streptococcus pneumoniae by the innate immune system.
- ST2 and IL-33 differentially regulate the innate immune response to Streptococcus pneumoniae
- MyD88-Dependent Signals Are Essential for the Host Immune Response in Experimental Brain Abscess1
- Enterococcus faecalis Glycolipids Modulate Lipoprotein-Content of the Bacterial Cell Membrane and Host Immune Response
- Pulmonary Lipopolysaccharide (LPS)-Binding Protein Inhibits the LPS-Induced Lung Inflammation In Vivo1
- TREM-1 Activation Alters the Dynamics of Pulmonary IRAK-M Expression In Vivo and Improves Host Defense during Pneumococcal Pneumonia1
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