Recognition of gram-negative bacteria and endotoxin by the innate immune system.
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Summary
A considerable body of evidence supports a model where LPS or LPS-containing particles form complexes with a serum protein known as L PS-binding protein; the LPS in this complex is subsequently transferred to another protein which binds LPS, CD14.
- Type
- review
- Published
- 1999-02-01
- Cited by
- 630
- References
- 36
- OpenAlex
- https://openalex.org/W1968241763
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39609266
Keywords
CD14, Lipopolysaccharide, Innate immune system, Gram-negative bacteria, Bacteria
References
- Recognition of bacterial endotoxins by receptor-dependent mechanisms.
- Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.
- Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- Complete cDNA encoding human phospholipid transfer protein from human endothelial cells.
- Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
- A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis.
- Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.
- Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection
- Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.
- Effects of site-directed mutagenesis of basic residues (Arg 94, Lys 95, Lys 99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation.
- The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105
- Phosphatidylinositides Bind to Plasma Membrane CD14 and Can Prevent Monocyte Activation by Bacterial Lipopolysaccharide*
- Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution.
- CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.
- Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function.
- ANIMAL MODELS OF SEPSIS AND SHOCK: A REVIEW AND LESSONS LEARNED
- Structure and function of lipopolysaccharide binding protein.
- Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages
- Chemistry and Algebra
Cited by
- Endotoxin Activity Assay: An Experience of a Southern-Italy Hospital
- Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes.
- The many roles of the class A macrophage scavenger receptor.
- Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.
- Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs.
- Heat shock pretreatment attenuates sepsis-associated encephalopathy in LPS-induced septic rats.
- NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes*
- Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo
- Polyvinylidene Fluoride Alters Inflammatory Responses by Activation-induced Cell Death in Macrophages
- Rôle des récepteurs Toll-like et de CD14 dans la réponse à Listeria monocytogenes et à la flagelline extraite de Salmonella typhimurium
- THE INTERELATIONSHIP BETWEEN CD14 AND LPS DURING MASTITIS: RELEASE OF SOLUBLE CD14 AND CYTOKINES BY BOVINE PMN FOLLOWING ACTIVATION WITH LPS
- Bioaerosol exposure assessment and the Limulus amoebocyte lysate assay
- Recreational exposure to freshwater cyanobacteria : epidemiology, dermal toxicity and biological activity of cyanobacterial lipopolysaccharides
- Characterization and expression analysis of bactericidal permeability-increasing protein (BPI) antimicrobial peptide gene from channel catfish Ictalurus punctatus.
- Interactions of intestinal epithelial cells with bacterial extracellular products
- Die transkriptionelle Regulation der Toll-like Rezeptoren (TLR2, TLR3 und TLR4) in mononukleären Phagozyten
- Mechanisms of immune activation during infection
- CHARACTERIZATION OF THE ROLES OF TWO REGULATORS OF VIRUS INFECTION: GP78 AND BPIFB3
- Immunologie de la polypose nasosinusienne
- Early detection of severe sepsis in the emergency room in adults - Clinical utility of prognostic markers
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