Heat-Killed Brucella abortus Induces TNF and IL-12p40 by Distinct MyD88-Dependent Pathways: TNF, Unlike IL-12p40 Secretion, Is Toll-Like Receptor 2 Dependent
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Summary
The data demonstrate that MyD88-dependent pathways are crucial for activation by HKBA and that TLR2 plays a role in TNF, but not IL-12p40 pathways activated by this microbial product.
- Type
- article
- Published
- 2003-08-01
- Cited by
- 96
- References
- 47
- OpenAlex
- https://openalex.org/W12874236
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23880347
Keywords
Computer science
References
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Cited by
- MyD88-Dependent Activation of B220−CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection1
- Regulatory role of natural killer (NK) cells on antibody responses to Brucella abortus
- The impaired Th1 immune response of C3HeB/FeJ mice infected with Leishmania amazonensis: lessons learned from immunotherapy and vaccines
- Immune response triggered by Brucella abortus following infection or vaccination.
- Central Role of MyD88-Dependent Dendritic Cell Maturation and Proinflammatory Cytokine Production to Control Brucella abortus Infection1
- Heat-killed and γ-irradiated Brucella strain RB51 stimulates enhanced dendritic cell activation, but not function compared with the virulent smooth strain 2308.
- Serving the new masters – dendritic cells as hosts for stealth intracellular bacteria
- Cellular bioterrorism: how Brucella corrupts macrophage physiology to promote invasion and proliferation.
- Comparison of blood profiles between healthy and Brucella affected cattle.
- Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1
- Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection?
- Deep sequencing-based expression transcriptional profiling changes during Brucella infection.
- Manipulation of mitogen‐activated protein kinase/nuclear factor‐κB‐signaling cascades during intracellular Toxoplasma gondii infection
- Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia.
- MyD88 and TLR9 are required for early control of Brucella ovis infection in mice.
- Macrophage‐elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88‐dependent TNF‐α production
- Immunomodulatory and cytotoxic effects of various Lactococcus strains on the murine macrophage cell line J774.1.
- Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection
- Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunity.
- Toll-Like Receptor 6 Plays an Important Role in Host Innate Resistance to Brucella abortus Infection in Mice
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