Missing pieces in the NF-kappaB puzzle.
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Summary
This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.
- Type
- review
- Published
- 2002-04-01
- Cited by
- 3,623
- References
- 155
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976382352
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15459299
Keywords
Biology, NF-κB, Computational biology, Genetics, Signal transduction
References
- Structure of NF-κB p50 homodimer bound to a κB site
- Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB
- Activation of NF‐kappa B in vivo is regulated by multiple phosphorylations.
- RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.
- Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions.
- The characterization of the promoter of the gene encoding the p50 subunit of NF‐kappa B indicates that it participates in its own regulation.
- A Toll-like receptor recognizes bacterial DNA
- TIRAP: an adapter molecule in the Toll signaling pathway
- The essential role of MEKK3 in TNF-induced NF-κB activation
- Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase
- IKKα controls formation of the epidermis independently of NF-κB
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK
- Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation1
- An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China
- Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
- Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.
- An N‐terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα
- Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment1
- Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase
- Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export
Cited by
- Local administration of IKK small molecule inhibitor may enhance fracture healing in osteoporosis patient.
- Molecular mechanisms underlying staphylococcal induced osteomyelitis.
- Gene expression profiling reveals a highly specialized genetic program of plasma cells.
- NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
- X-ray Crystal Structure of an IκBβ·NF-κB p65 Homodimer Complex*
- Alcohol potentiates hepatitis C virus replicon expression
- Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2.
- Direct transcriptional regulation of RelB by 1alpha,25-dihydroxyvitamin D3 and its analogs: physiologic and therapeutic implications for dendritic cell function.
- Keeping cartographers busy
- Interleukin-10 Inhibits Interleukin-12 p40 Gene Transcription by Targeting a Late Event in the Activation Pathway
- The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation.
- RIP Links TLR4 to Akt and Is Essential for Cell Survival in Response to LPS Stimulation
- AIP1/DAB2IP, a Novel Member of the Ras-GAP Family, Transduces TRAF2-induced ASK1-JNK Activation*
- Identification of target genes involved in the antiproliferative effect of glucocorticoids reveals a role for nuclear factor-(kappa)B repression.
- Glucocorticoids: Protectors of the Brain during Innate Immune Responses
- Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level.
- Ordered recruitment: gene-specific mechanism of transcription activation.
- Biomechanical stress induces IL-6 expression in smooth muscle cells via Ras/Rac1-p38 MAPK-NF-kappaB signaling pathways.
- Crossroads of Estrogen Receptor and NF-κB Signaling
- Life and death of lymphocytes: a role in immunesenescence
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