The response of Parp knockout mice against DNA damaging agents.
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Summary
Findings suggest that loss of Parp activity could contribute to post-irradiation tissue hemorrhage in Parp(-/-) mice.
- Type
- article
- Published
- 2000-04-01
- Cited by
- 138
- References
- 46
- OpenAlex
- https://openalex.org/W2022353228
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24631280
Keywords
Poly ADP ribose polymerase, DNA damage, Biology, DNA repair, Spleen
References
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- Studies on the diabetogenic action of streptozotocin (NSC-37917).
- pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans 1
- Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
- Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
- Stability and capacity of dimethylnitrosamine-induced O6-methylguanine repair system in rat liver.
- Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
- Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.
- Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
- Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
- DNA repair: PARP - another guardian angel?
- Involvement of poly(ADP-ribose) polymerase in base excision repair.
- Isolation and Characterization of the cDNA Encoding Bovine Poly(ADP-ribose) Glycohydrolase*
- Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets.
- Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
- Occult blood appearance in feces and tissue hemorrhages in mice after whole body x-irradiation.
- Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
- The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
- Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.
- Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development.
Cited by
- Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
- Human Poly(ADP-Ribose) Polymerase-1-Expressing Embryonic Stem Cells and Mice : Generation and Phenotypic Characterization
- Biochemical characterization of Aprataxin, the protein deficient in Ataxia with Oculomotor Apraxia type 1
- PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses
- Rôles de la poly (ADP-ribose) polymérase-3 (PARP-3) dans la réponse cellulaire aux dommages dans l'ADN et la progression mitotique
- The potential of the PARP-1 inhibitor, AGO14699, in human cancers defective in homologous recombination DNA repair
- Assessment of Unique and Combined Functions of Poly(ADP-Ribose) Polymerases by Using RNA Interference
- Investigation of the role of poly(ADP-ribose)polymerase inhibition in topoisomerase I poison-induced cytotoxicity
- Histone ADP-ribosylation by Poly(ADP-ribose) Polymerase 1 (PARP1) Facilitates Inflammatory Gene Transcription by Directly Altering Nucleosome Structure
- Clinical and laboratory studies to support the first-in-human trial of a novel poly(ADP-ribose) polymerase inhibitor in combination with temozolomide
- PARP inhibition tested in a mammary epithelial cell line model
- Clinical trials in triple negative breast cancer.
- Funktionelle Interaktionen zwischen Wildtyp-p53, Rad51 und Poly-ADP-Phosphoribosyl-Transferase bei der Kontrolle von DNA-Rekombinationsprozessen
- Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeast.
- Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
- Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse
- Potential Therapeutic Implications of Cancer Stem Cells in Glioblastoma
- Purification and characterization of poly(ADP-ribose) polymerase from Sarcophaga peregrina
- Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications.
- Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors.
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