Replication stress activates DNA polymerase alpha-associated Chk1
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Summary
DNA Polα is identified as an important component of the signal transduction cascade that activates the intra-S checkpoint and the ability to efficiently phosphorylate Chk1 in the context of DNA Polα complexes is correlated with suppression of DNA damage following replication stress.
- Type
- article
- Published
- 2009-02-01
- Cited by
- 35
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W1984596717
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46137828
Keywords
Biology, DNA damage, CHEK1, DNA replication, G2-M DNA damage checkpoint
References
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- Mechanisms of apoptosis induction by nucleoside analogs
- Functions of eukaryotic DNA polymerases.
- DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*
- Checking on DNA damage in S phase
- DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication.
- Checkpoints: controls that ensure the order of cell cycle events.
- Functional consequences of the arabinosylcytosine structural lesion in DNA.
- Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.
- Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
- Dephosphorylation of Histone γ-H2AX during Repair of DNA Double-Strand Breaks in Mammalian Cells and its Inhibition by Calyculin A
- Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
- Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.
- TopBP1 activates the ATR-ATRIP complex.
Cited by
- Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
- Tight Chk1 Levels Control Replication Cluster Activation in Xenopus
- Roles of Chk1 in Cell Biology and Cancer Therapy
- Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase
- A Functional Approach Reveals a Genetic and Physical Interaction between Ribonucleotide Reductase and CHK1 in Mammalian Cells
- The unpredictable caspase-2: what can it do?
- Nuclear Accumulation of the Papillomavirus E1 Helicase Blocks S-Phase Progression and Triggers an ATM-Dependent DNA Damage Response
- Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
- Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo
- Preclinical Development of the Novel Chk1 Inhibitor SCH900776 in Combination with DNA Damaging Agents and Antimetabolites
- Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase α
- Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation*
- Cancer TARGETases: DSB repair as a pharmacological target.
- A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function
- Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress
- Fundamental Aspects of DNA Replication
- Targeting the ATR-CHK1 Axis in Cancer Therapy
- Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
- Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities
- Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene
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