Doxorubicin Activates ATM-dependent Phosphorylation of Multiple Downstream Targets in Part through the Generation of Reactive Oxygen Species*
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Summary
The requirement for the serine/threonine protein kinase ATM in coordinating the cellular response to DNA damage induced by ionizing radiation has been studied extensively and it is observed that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways.
- Type
- article
- Published
- 2004-12-17
- Cited by
- 262
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W2036575025
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20849294
Keywords
Phosphorylation, DNA damage, Doxorubicin, Cell biology, Chemistry
References
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- ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
- The role of ATM and ATR in DNA damage-induced cell cycle control.
- Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
- ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
- Imparied glutathione biosynthesis in cultured human ataxia-telangiectasia cells.
- Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
- Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
- Protein kinase CK1 is a p53‐threonine 18 kinase which requires prior phosphorylation of serine 15
- ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53*
- Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs.
- Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors.
- DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139*
- Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
- Multisite phosphorylation provides sophisticated regulation of transcription factors.
Cited by
- DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates
- Study of the in vivo phosphorylation of E2F1 on Ser403.
- Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
- High-throughput screening identifies aclacinomycin as a radiosensitizer of EGFR-mutant non-small cell lung cancer.
- Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer
- Characterization of the Molecular Signal Transduction Pathway of the Tyrosine Kinase Abl1 in Response to Genotoxic Stress
- Apoptotic cell death in TrkA-overexpressing cells: kinetic regulation of ERK phosphorylation and caspase-7 activation.
- INHIBITION OF PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) SIGNALLING LEADS TO RESISTANCE TO CHEMOTHERAPEUTIC AGENTS IN HUMAN CANCER CELLS
- Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
- Chemo-protective and regenerative effects of diarylheptanoids from the bark of black alder (Alnus glutinosa) in human normal keratinocytes.
- Two for the Price of One: G Protein-Dependent and -Independent Functions of RGS6 In Vivo.
- Transcriptional and post-transcriptional regulation in testicular toxicity
- CHK2 is Negatively Regulated by Protein Phosphatase 2A
- Docking-dependent regulation of checkpoint kinase chk1 by the growth regulator p21WAF1
- Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage
- Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular‐based therapy
- Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide
- Cellular stress responses in equine tendon fibroblast monolayers
- Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin
- A study of the role of ATM mutations in the pathogenesis of B-cell chronic lymphocytic leukaemia
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