Prognostic value of GRIM-19, NF-κB and IKK2 in patients with high-grade serous ovarian cancer.
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Summary
IG analyses of GRIM-19, IKK2 and NF-κB may be important in the attempt to provide prognostic values for relapse and response to treatment in patients with HGSC, and are potential predictors of response to platinum-based chemotherapy in HGSC.
- Type
- article
- Published
- 2018-01-01
- Cited by
- 5
- References
- 39
- OpenAlex
- https://openalex.org/W2773450347
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34559795
Keywords
Debulking, Medicine, Internal medicine, Oncology, Ovarian cancer
References
- Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli
- GRIM-19 expression is a potent prognostic marker in colorectal cancer.
- Upregulation of GRIM-19 inhibits the growth and invasion of human breast cancer cells.
- Expression of classical NF‐κB pathway effectors in human ovarian carcinoma
- Identification of GRIM-19, a Novel Cell Death-regulatory Gene Induced by the Interferon-β and Retinoic Acid Combination, Using a Genetic Approach*
- Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease.
- p53 stabilization is decreased upon NFκB activation
- GRIM‐19, a death‐regulatory gene product, suppresses Stat3 activity via functional interaction
- Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells*
- TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens.
- Survival impact of complete cytoreduction to no gross residual disease for advanced-stage ovarian cancer: a meta-analysis.
- Expression and clinical significance of GRIM-19 in lung cancer
- Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features
- Survey on Knowledge, Attitudes, and Training Needs of Italian Residents on Genetic Tests for Hereditary Breast and Colorectal Cancer
- Immunohistochemical analysis of NF‐κB signaling proteins IKKε, p50/p105, p52/p100 and RelA in prostate cancers
- NF-kB in development and progression of human cancer
- "Platinum resistant" ovarian cancer: what is it, who to treat and how to measure benefit?
- Cytokine-induced tumor suppressors: a GRIM story
- Metadherin, p50, and p65 Expression in Epithelial Ovarian Neoplasms: An Immunohistochemical Study
- NF-κB transcription factors are co-expressed and convey poor outcome in ovarian cancer
Cited by
- Clinico‑morphological aspects and new immunohistochemistry characteristics of ovarian high‑grade serous carcinoma
- OLFM4 Enhances STAT3 Activation and Promotes Tumor Progression by Inhibiting GRIM19 Expression in Human Hepatocellular Carcinoma
- Interaction of M2 macrophages and endometrial cells induces downregulation of GRIM-19 in endometria of adenomyosis.
- Müsinöz Olmayan Akciğer Adenokarsinomlarında Caspase-3 ve GRIM-19 Ekspresyonu ile Bu Proteinlerin Klinikopatolojik Önemi
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