Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
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Summary
High-resolution crystal structures of the receptor-binding domain of the spike protein of SARS-CoV-2 and SARS -CoV in complex with ACE2 provide insights into the binding mode of these coronaviruses and highlight essential ACE2-interacting residues.
- Type
- article
- Published
- 2020-03-30
- Cited by
- 5,536
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W3014067025
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:214731733
Keywords
Spike Protein, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Receptor, Coronavirus disease 2019 (COVID-19), 2019-20 coronavirus outbreak
References
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- Structural Basis of Neutralization by a Human Anti-severe Acute Respiratory Syndrome Spike Protein Antibody, 80R
- Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
- Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody
- Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus
- Phaser crystallographic software
- Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
- Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
- Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
- Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis
- A new coronavirus associated with human respiratory disease in China
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
- Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
- Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
- Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
- Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses
Cited by
- In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs
- Effect of Cysteine Oxidation in SARS-CoV-2 Receptor-Binding Domain on Its Interaction with Two Cell Receptors: Insights from Atomistic Simulations
- MIL-101 (Fe) @Ag Rapid Synergistic Antimicrobial and Biosafety Evaluation of Nanomaterials
- Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein
- AGTR2, One Possible Novel Key Gene for the Entry of SARS-CoV-2 Into Human Cells
- Computational Prediction of Mutational Effects on SARS-CoV-2 Binding by Relative Free Energy Calculations
- Predicting COVID-19 malignant progression with AI techniques
- SARS-CoV-2 (COVID-19) by the numbers
- Structural basis of receptor recognition by SARS-CoV-2
- Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS-CoV-2 spike protein
- Coronavirus SARS‐CoV‐2: filtering fact from fiction in the infodemic
- Re-insights into origin and adaptation of SARS-CoV-2
- Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses
- Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
- Comparative ACE2 variation and primate COVID-19 risk
- Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir
- The Science Underlying COVID-19: Implications for the Cardiovascular System.
- Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2
- Potential host range of multiple SARS-like coronaviruses and an improved ACE2-Fc variant that is potent against both SARS-CoV-2 and SARS-CoV-1
- Rapid in silico design of antibodies targeting SARS-CoV-2 using machine learning and supercomputing
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