In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs
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Summary
The present study supported the zoonotic origin of SARS‐CoV‐2 from a bat and revealed that TLR4 may have a crucial role in the virus‐induced inflammatory consequences associated with COVID‐19, and selective targeting ofTLR4‐spike protein interaction by designing competitive TLR 4‐antagonists could pave a new way to treat COVID'19.
- Type
- article
- Published
- 2020-05-08
- Cited by
- 443
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W32383269
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:218557989
Keywords
Computer science
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