Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein
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Summary
This work represents an important disorder-based outlook of an interplay between the renin-angiotensin-aldosterone system and SARS-CoV-2 and suggests that consideration of the intrinsic disorder phenomenon should be added to the modern arsenal of means for drug development.
- Type
- letter
- Published
- 2018-04-04
- Cited by
- 151
- References
- 236
- Access
- Open access
- OpenAlex
- https://openalex.org/W2796346355
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:221470978
Keywords
Biology, Spike Protein, Spike (software development), Coronavirus, Computational biology
References
- Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
- DISOPRED3: precise disordered region predictions with annotated protein-binding activity
- Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors
- An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology
- The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China
- Protein disorder and the evolution of molecular recognition: theory, predictions and observations.
- Coronaviruses: An Overview of Their Replication and Pathogenesis
- Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A Perpetual Challenge
- Identification and functions of usefully disordered proteins.
- Phylogenetic analysis of the full‐length SARS‐CoV sequences: Evidence for phylogenetic discordance in three genomic regions
- Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond
- The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
- Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
- Fuzzy complexes: Specific binding without complete folding
- Length-dependent prediction of protein intrinsic disorder
- Type II transmembrane serine proteases.
- Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1
- The multifaceted roles of intrinsic disorder in protein complexes
- Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes.
- Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
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- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- Deep convolutional neural networks for predicting leukemia-related transcription factor binding sites from DNA sequence data
- Coronavirus: Scientometrics of 50 Years of Global Scientific Productions
- SARS-CoV-2/COVID-19 and Advances in Developing Potential Therapeutics and Vaccines to Counter this Emerging Pandemic Virus – A Review
- The genetic sequence, origin, and diagnosis of SARS-CoV-2
- COVIDier: A Deep-learning Tool For Coronaviruses Genome And Virulence Proteins Classification
- Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients
- SARS-CoV, MERS-CoV and SARS-CoV-2 infections in pregnancy and fetal development
- Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement
- Role of inflammatory markers in corona virus disease (COVID-19) patients: A review
- An Introduction to SARS Coronavirus 2; Comparative Analysis with MERS and SARS Coronaviruses: A Brief Review
- Current Understanding, Knowledge Gaps and a Perspective on the Future of COVID-19 Infections: A Systematic Review
- Molecular diagnosis of COVID-19: Current situation and trend in China (Review)
- Genetic and pathogenic characterization of SARS-CoV-2: a review
- The SARS-CoV-2 ORF10 is not essential in vitro or in vivo in humans
- SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic
- The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies
- Insights into the Origin, Transmission and Outbreak of Coronavirus Disease (Covid 19): A Recent Study
- Coronavirus and Its effect on the respiratory system: Is there any association between pneumonia and immune cells
- Emergence of Avian coronavirus genotype GI-11 in Colombia
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