Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive
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Summary
It is concluded that the RNA-synthesizing activities observed in de novo and primer-dependent polymerase and terminal transferase assays cannot be attributed to recombinant EAV nsp9-RdRp and the potential pitfalls of characterizing polymerases using highly sensitive biochemical assays are illustrated.
- Type
- article
- Published
- 2015-10-23
- Cited by
- 10
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2176417755
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32357484
Keywords
Biology, RNA-dependent RNA polymerase, RNA polymerase, Polymerase, RNA
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- Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates
- An attempt to unify the structure of polymerases.
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- Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase
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Cited by
- Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes
- Antiviral activity of K22 against members of the order Nidovirales
- Production of a novel Affimer based biosensor for the detection of porcine reproductive and respiratory syndrome virus nucleocapsid protein.
- Nonstructural protein 9 residues 586 and 592 are critical sites in determining the replication efficiency and fatal virulence of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus
- Mapping the Nonstructural Protein Interaction Network of Porcine Reproductive and Respiratory Syndrome Virus
- Antiviral Strategies of Chinese Herbal Medicine Against PRRSV Infection
- Replication of the coronavirus genome: A paradox among positive-strand RNA viruses
- Paraoxonase-1 Facilitates PRRSV Replication by Interacting with Viral Nonstructural Protein-9 and Inhibiting Type I Interferon Pathway
- Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus
- Classification, replication, and transcription of Nidovirales
- Porcine reproductive and respiratory syndrome virus nsp2 protects viral RNA-dependent RNA polymerase from autophagic degradation
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