Structural and Functional Characterization of an Influenza Virus RNA Polymerase-Genomic RNA Complex
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Summary
It is suggested that the interaction with the template is sufficient to induce a significant conformation switch in the polymerase complex, as shown in the case of the monomeric polymerase-vRNA complexes obtained after replication in vivo.
- Type
- article
- Published
- 2010-08-11
- Cited by
- 48
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W1979964368
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14779056
Keywords
Biology, Polymerase, RNA-dependent RNA polymerase, RNA polymerase I, Molecular biology
References
- Differential activation of the influenza virus polymerase via template RNA binding
- Xmipp: An Image Processing Package for Electron Microscopy
- Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates
- Orthomyxovirus replication, transcription, and polyadenylation.
- Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo.
- Polyadenylation sites for influenza virus mRNA
- Determination of influenza virus proteins required for genome replication
- Influenza virus RNA replication in vitro: synthesis of viral template RNAs and virion RNAs in the absence of an added primer
- The influenza virus panhandle is involved in the initiation of transcription
- Direct Evidence that the Poly(A) Tail of Influenza A Virus mRNA Is Synthesized by Reiterative Copying of a U Track in the Virion RNA Template
- Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro
- RNA polymerase of influenza virus: role of NP in RNA chain elongation.
- Crucial role of CA cleavage sites in the cap‐snatching mechanism for initiating viral mRNA synthesis
- Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site
- Two Aromatic Residues in the PB2 Subunit of Influenza A RNA Polymerase Are Crucial for Cap Binding*
- Genetic variability of Hong Kong (H3N2) influenza viruses: spontaneous mutations and their location in the viral genome.
- Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit
- A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs
- Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase
- Definition of the minimal viral components required for the initiation of unprimed RNA synthesis by influenza virus RNA polymerase.
Cited by
- Importance of interferon inducible trans-membrane proteins and retinoic acid inducible gene I for influenza virus replication: A review
- Interacciones del virus de la gripe con la célula hospedadora: identificación de dianas celulares con potencial para la inhibición del virus
- The influenza virus RNA synthesis machine
- Early host response and immune signaling to 2009 pandemic influenza A (H1N1) viruses in primary cell culture models.
- DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity
- Architecture and regulation of negative-strand viral enzymatic machinery
- Activation of the Interferon Induction Cascade by Influenza A Viruses Requires Viral RNA Synthesis and Nuclear Export
- The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription
- Organization of the Influenza Virus Replication Machinery
- Host Restriction of Influenza Virus Polymerase Activity by PB2 627E Is Diminished on Short Viral Templates in a Nucleoprotein-Independent Manner
- The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes
- Apical Transport of Influenza A Virus Ribonucleoprotein Requires Rab11-positive Recycling Endosome
- Structure and assembly of the influenza A virus ribonucleoprotein complex
- Oligomerization paths of the nucleoprotein of influenza A virus.
- The RNA synthesis machinery of negative-stranded RNA viruses.
- The polymerase of negative-stranded RNA viruses
- Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity.
- Influenza virus activation of the interferon system
- The RNA-dependent RNA polymerase of the influenza A virus
- Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication
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