Paraoxonase-1 Facilitates PRRSV Replication by Interacting with Viral Nonstructural Protein-9 and Inhibiting Type I Interferon Pathway
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Summary
The data demonstrate that PON1 facilitates PRRSV replication by interacting with Nsp9 and inhibiting the type I IFN signaling pathway, suggesting that Pon1 may be an additional component of the anti-PRRSV defenses.
- Type
- article
- Published
- 2022-05-31
- Cited by
- 7
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W4281701150
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:249331462
Keywords
PON1, Gene knockdown, Porcine reproductive and respiratory syndrome virus, Viral replication, Virology
References
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- Immunomodulatory functions of type I interferons
- Monitoring of the lactonase activity of paraoxonase-1 enzyme in HIV-1-infection
- Antiviral activity of type I and type III interferons against porcine reproductive and respiratory syndrome virus (PRRSV).
- Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein
- Sequence identification, chromosomal mapping and tissue specific expression of the porcine paraoxonase 1 (PON1) gene
- Maternal chronic hepatitis B virus is implicated with low neonatal paraoxonase/arylesterase activities.
- Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV)
- The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis
- Porcine Reproductive and Respiratory Syndrome
- PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity
- Study of factors influencing the decreased HDL associated PON1 activity with aging.
- The interaction between host Annexin A2 and viral Nsp9 is beneficial for replication of porcine reproductive and respiratory syndrome virus.
- The PRRSV replicase: Exploring the multifunctionality of an intriguing set of nonstructural proteins
- The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro
- The paraoxonase 1, 2 and 3 in humans.
- Oxidant and antioxidant of arylesterase and paraoxonase as biomarkers in patients with hepatitis C virus.
Cited by
- Antiviral Activity Against SARS-CoV-2 Variants Using in Silico and in Vitro Approaches
- The crucial regulatory role of type I interferon in inflammatory diseases
- Classification, replication, and transcription of Nidovirales
- Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9–mediated inhibition of N6-methyladenosine demethylase FTO
- Innate Immune Evasion of PRRSV nsp11 through Degradation of the HDAC2 by Its Endoribonuclease Activity
- SERTAD3 interacts with porcine reproductive and respiratory syndrome virus nonstructural protein 9 and inhibits virus replication.
- Strategies and scheming: the war between PRRSV and host cells
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