Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase
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Summary
Experimental evidence is provided that nsp13 and nsp12 can function in a concerted manner to improve the efficiency of viral replication and enhance the understanding of nSp13 function during SARS-CoV RNA synthesis.
- Type
- article
- Published
- 2012-05-15
- Cited by
- 184
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W1995042237
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16126939
Keywords
Helicase, Nucleic acid, RNA, DNA, Biochemistry
References
- Further Characterization of the Helicase Activity of eIF4A
- SARS-Coronavirus Replication/Transcription Complexes Are Membrane-Protected and Need a Host Factor for Activity In Vitro
- A fork‐clearing role for UvrD
- A new RNA helicase isolated from HeLa cells that catalytically translocates in the 3' to 5' direction.
- Rapid kinetic techniques.
- Helicase-catalyzed DNA unwinding.
- Pestivirus NS3 (p80) protein possesses RNA helicase activity
- Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus Helicase
- Ensemble Methods for Monitoring Enzyme Translocation along Single Stranded Nucleic Acids
- Analysis of Intraviral Protein-Protein Interactions of the SARS Coronavirus ORFeome
- Kinetic Measurement of the Step Size of DNA Unwinding by Escherichia coli UvrD Helicase
- The Bloom's syndrome gene product is homologous to RecQ helicases.
- Lung pathology of fatal severe acute respiratory syndrome
- SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
- Intermediates revealed in the kinetic mechanism for DNA unwinding by a monomeric helicase
- Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement.
- Unzipping mechanism of the double-stranded DNA unwinding by a hexameric helicase: the effect of the 3' arm and the stability of the dsDNA on the unwinding activity of the Escherichia coli DnaB helicase.
- The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent
- Kinetics of DNA Unwinding by the RecD2 Helicase from Deinococcus radiodurans
- Kinetic mechanism of DNA unwinding by the BLM helicase core and molecular basis for its low processivity.
Cited by
- Continuous and Discontinuous RNA Synthesis in Coronaviruses
- Anti-SARS coronavirus agents: a patent review (2008 – present)
- Nucleocapsid Phosphorylation and RNA Helicase DDX1 Recruitment Enables Coronavirus Transition from Discontinuous to Continuous Transcription
- Atlas of coronavirus replicase structure
- Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
- Evaluation of SSYA10-001 as a Replication Inhibitor of Severe Acute Respiratory Syndrome, Mouse Hepatitis, and Middle East Respiratory Syndrome Coronaviruses
- SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
- Functional Cross-talk between Distant Domains of Chikungunya Virus Non-structural Protein 2 Is Decisive for Its RNA-modulating Activity*
- Antiviral Drugs Specific for Coronaviruses in Preclinical Development
- What we know but do not understand about nidovirus helicases
- Development of chemical inhibitors of the SARS coronavirus: Viral helicase as a potential target
- Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex
- Severe Acute Respiratory Syndrome Coronavirus Replication Inhibitor That Interferes with the Nucleic Acid Unwinding of the Viral Helicase
- STRUCTURAL AND BIOCHEMICAL BASIS FOR THE DIFFERENCE IN THE HELICASE ACTIVITY OF TWO DIFFERENT CONSTRUCTS OF SARS-COV HELICASE
- One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
- Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive
- SARS coronavirus without reservoir originated from an unnatural evolution, experienced the reverse evolution, and finally disappeared in the world
- Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens
- Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase
- The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing
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