Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses.
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Summary
It is found that lincRNA expression is strikingly tissue-specific compared with coding genes, and that l incRNAs are typically coexpressed with their neighboring genes, albeit to an extent similar to that of pairs of neighboring protein-coding genes.
- Type
- article
- Published
- 2011-09-15
- Cited by
- 3,396
- References
- 61
- Access
- Open access
- OpenAlex
- https://openalex.org/W2160333540
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13856113
Keywords
Biology, Intergenic region, Computational biology, Gene, Non-coding RNA
References
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- Disruption of imprinting caused by deletion of the H19 gene region in mice
- Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
- RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters
- Ab initio reconstruction of transcriptomes of pluripotent and lineage committed cells reveals gene structures of thousands of lincRNAs
- The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin
- Ripples from neighbouring transcription
- Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
- Fast Statistical Alignment
- A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression
- Divergent transcription from active promoters
- RNA traffic control of chromatin complexes
- Genomic and Transcriptional Co-Localization of Protein-Coding and Long Non-Coding RNA Pairs in the Developing Brain
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- Probabilistic Models for Collecting, Analyzing, and Modeling Expression Data
- Methods for the Study of Long Noncoding RNA in Cancer Cell Signaling
- Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis.
- Whole Transcriptome RNA-Seq Analysis of Breast Cancer Recurrence Risk Using Formalin-Fixed Paraffin-Embedded Tumor Tissue
- Non-coding RNAs in DNA damage response.
- A New Method for Stranded Whole Transcriptome RNA-seq
- Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect
- Distinct Patterns of Genetic Variations in Potential Functional Elements in Long Noncoding RNAs
- Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals
- Tissue-specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures of Cardio-metabolic Diseases
- Regulation of metabolism by long, non-coding RNAs
- Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications
- Identification of cancer-related lncRNAs through integrating genome, regulome and transcriptome features.
- lincRNA HOTAIR as a novel promoter of cancer progression
- Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing
- Genome-wide profiling of the C. elegans dsRNAome
- The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma
- MicroRNAs and lncRNAs in senescence: A re‐view
- It’s More Than Stamp Collecting: How Genome Sequencing Can Unify Biological Research
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