Short RNAs are transcribed from repressed Polycomb target genes and interact with Polycomb Repressive Complex-2
Explore this paper's citation graph
Summary
A new class of short RNAs are identified, ~50-200 nucleotides in length, transcribed from the 5′-end of polycomb target genes in primary T-cells and embryonic stem cells and it is proposed that short RNAs play a role in the association of PRC2 with its target genes.
- Type
- article
- Published
- 2010-06-01
- Cited by
- 406
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972170164
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15094615
Keywords
Biology, Polycomb-group proteins, Genetics, Gene, Repressor
References
- Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
- Polycomb proteins targeted by a short repeat RNA to the mouse X-chromosome
- The genomic landscape of histone modifications in human T cells
- Genome-wide analysis of Polycomb targets in Drosophila melanogaster
- Tiny RNAs associated with transcription start sites in animals
- Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
- Regulation of Hox gene activity by transcriptional elongation in Drosophila
- Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
- Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
- High-resolution profiling of histone methylations in the human genome.
- Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
- Chromatin signatures of pluripotent cell lines
- Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.
- Divergent transcription from active promoters
- Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells
- Hierarchical recruitment of polycomb group silencing complexes.
- Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs
- Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation.
- Polycomb silencing blocks transcription initiation.
Cited by
- Epigenetics and chromatin dynamics: a review and a paradigm for functional disorders
- A double take on bivalent promoters.
- Non-coding RNAs and the borders of heterochromatin
- Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention
- Pervasive lncRNA binding by epigenetic modifying complexes--The challenges ahead.
- Etude du réseau transcriptionnel du gène Xist, acteur principal de l'inactivation du chromosome X
- Leukemogenic Mechanisms of MLL Fusion Proteins.
- H3K9/HP1 and Polycomb: two key epigenetic silencing pathways for gene regulation and embryo development.
- The molecular mechanism of the aberrant expression of the B-cell specific PAX5 gene in t(8;21) AML
- Repressive Transcription
- Functional analysis of long noncoding RNAs in development and disease.
- Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy
- ALP1 and ELP1 – novel genetic modifiers of LIKE HETEROCHROMATIN PROTEIN 1 participate in Polycomb mediated gene repression in Arabidopsis
- Gene Regulation mediated by Bivalent Chromatin Domains
- Influence of CpG islands on chromatin structure
- Regulation of CpG island promoters by the histone methyltransferase MLL2
- Examining the contribution of chromatin and chromatin associated factors to transcription regulation
- On Identifying Signatures of Positive Selection in Human Populations: A Dissertation
- Differential chromatin topology and transcription factor enhancer binding regulate spatiotemporal gene expression in limb development
- Analyses des régulations épigénétiques des éléments transposables chez Drosophila melanogaster
Related papers
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- Interactions between DNA-bound repressors govern regulation by the lambda phage repressor.
- Further structural and functional analogies between the repressor regions of phages P22 and λ
- Lambda cI repressor mutants altered in transcriptional activation.
- Control of lambda repressor synthesis.
- Kinetics of RecA protein-directed inactivation of repressors of phage lambda and phage P22.
- Cellular levels of the prophage lambda and 434 repressors.
- Studies of a thermolabile repressor.
- Control of bacteriophage lambda repressor synthesis: regulation of the maintenance pathway of the cro and cI products.
- Expression of two soybean resistance gene candidates shows divergence of paralogous single-copy genes