The mammalian epigenome.
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Summary
Current research efforts are reviewed, with an emphasis on large-scale studies, emerging technologies, and challenges ahead.
- Type
- review
- Published
- 2007-02-23
- Cited by
- 2,150
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W2134087142
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2722988
Keywords
Biology, Epigenome, Computational biology, Genetics, Evolutionary biology
References
- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
- The fundamental role of epigenetic events in cancer
- CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
- Epigenetic Reprogramming in Mammalian Development
- Evidence for an instructive mechanism of de novo methylation in cancer cells
- A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
- A blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop.
- A physical map of the human genome
- DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project
- Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4
- The genomic landscape of histone modifications in human T cells
- Genome-wide analysis of Polycomb targets in Drosophila melanogaster
- Transposon-free regions in mammalian genomes.
- Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.
- Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3
- The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.
- Global and Hox-specific roles for the MLL1 methyltransferase.
- Highly parallel genomic assays
- Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome
- Distinct epigenetic changes in the stromal cells of breast cancers
Cited by
- Translational control of gene expression from transcripts to transcriptomes.
- PR-Set7 Establishes a Repressive trans-Tail Histone Code That Regulates Differentiation
- Inferring causal relationships among different histone modifications and gene expression.
- BRG1 requirement for long-range interaction of a locus control region with a downstream promoter
- A novel mechanism of epigenetic regulation: nucleosome-space occupancy.
- Methylation analysis by DNA immunoprecipitation
- Integrating post‐transcriptional regulation into the embryonic stem cell gene regulatory network
- Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study
- Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers.
- Targeted DNA Methylation Analysis by High Throughput Sequencing in Porcine Peri-attachment Embryos
- DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon–intron structure
- A wavelet-based method to exploit epigenomic language in the regulatory region
- The impact of genomics on oncology nursing.
- Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer.
- 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain
- Cytochrome P450 1A1 and 1B1 promoter CpG island methylation regulates rat liver injury induced by isoniazid
- Fast detection of differential chromatin domains with SCIDDO
- THE LINKAGE BETWEEN TRANSCRIPTION CONTROL AND EPIGENETIC REGULATION: THE SNAIL STORY AND BEYOND
- Post-zygotic Genetic Variation in Health and Disease
- Methylation of histone H3 lysine 27 associated with apoptosis in osteosarcoma cells induced by staurosporine.
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