The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.
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Summary
It is demonstrated that this domain specifically recognizes DNA with unmethylated CpG sequences, and was corroborated in vivo in reporter assays utilizing the DNA-binding properties of the MT domain in a hybrid MT-VP16 transactivator construct.
- Type
- article
- Published
- 2002-02-15
- Cited by
- 249
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985171686
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1414834
Keywords
Biology, Molecular biology, CpG site, DNA, DNA-binding domain
References
- A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
- DNA methyltransferase Dnmt1 associates with histone deacetylase activity
- Methylation-Mediated Transcriptional Silencing in Euchromatin by Methyl-CpG Binding Protein MBD1 Isoforms
- The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX
- An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes.
- Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.
- Determining the DNA bending angle induced by non-specific high mobility group-1 (HMG-1) proteins: a novel method.
- Chromatin‐related properties of CBP fused to MLL generate a myelodysplastic‐like syndrome that evolves into myeloid leukemia
- Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.
- Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression.
- MLL rearrangements in haematological malignancies: lessons from clinical and biological studies
- MLL and CREB Bind Cooperatively to the Nuclear Coactivator CREB-Binding Protein
- A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins
- A vector for expressing GAL4(1-147) fusions in mammalian cells.
- Altered Hox expression and segmental identity in Mll-mutant mice
- Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice.
- The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia.
- Tandem duplication of the MLL gene in myelodysplastic syndrome‐derived overt leukemia with trisomy 11
- Polycombing the genome: PcG, trxG, and chromatin silencing.
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
Cited by
- A double take on bivalent promoters.
- Histone modifications across the cell cycle in undifferentiated and differentiating mouse embryonic stem cells
- TET1: A UNIQUE DNA DEMETHYLASE FOR MAINTENANCE OF DNA METHYLATION PATTERN
- Mechanisms of MLL Fusion Protein-Mediated Leukemic Transformation
- Introduction—Epiphanies in Epigenetics
- Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
- Studying the role of the fusion protein MLL-AF4 in leukemogenesis with the help of siRNAs
- Influence of CpG islands on chromatin structure
- Regulation of CpG island promoters by the histone methyltransferase MLL2
- Role of CpG island methylation and MBD2 in immune cell gene regulation
- Global DNA Demethylation During Erythropoiesis: A Dissertation
- An investigation into the role of MLL in murine haematopoiesis
- Duale PI3K/mTOR-Inhibition zeigt antileukämische Wirkung in MLL-rearrangierter akuter myeloischer Leukämie
- Role of Penaeus monodon hemocyte homeostasis associated protein (PmHHAP) in regulation of caspase-mediated apoptosis.
- Investigation of the role of MLL-ENL in leukaemogenesis.
- Characterization of Drosophila Menin Protein Interactions and a Potential Role for Menin in the Insulin Signalling Pathway
- Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells
- Contrôle de l'expression du gène HOXA9 dans les cellules souches/progénitrices hématopoïétiques : rôle des enzymes épigénétiques MOZ et MLL, et du facteur de polyadénylation Symplekin
- TRITHORAX, a Global Transcription Activator/Maintenance Protein of Drosophila melanogaster, Is Associated with the Nuclear Matrix
- Defining the protein complement of CpG islands
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