Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
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Summary
The results demonstrate that loss of Dnmt1 causes cell-type–specific changes in gene expression that impinge on several pathways, including expression of imprinted genes, cell-cycle control, growth factor/receptor signal transduction and mobilization of retroelements.
- Type
- article
- Published
- 2001-01-01
- Cited by
- 741
- References
- 52
- OpenAlex
- https://openalex.org/W1494290222
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19847763
Keywords
Biology, DNA methylation, Epigenetics, DNMT1, DNA demethylation
References
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- CpG methylation is maintained in human cancer cells lacking DNMT1
- Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
- DNA methyltransferase Dnmt1 associates with histone deacetylase activity
- Cancer-epigenetics comes of age
- DNA hypomethylation leads to elevated mutation rates
- The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
- Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
- Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens
- Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
- Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells.
- Transcriptional noise and the evolution of gene number.
- Molecular cloning and expression of mouse placental lactogen I complementary deoxyribonucleic acid.
- DNA methylation and imprinting: why bother?
- Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation
- Does DNA methylation control transposition of selfish elements in the germline?
- Suppression of intestinal neoplasia by DNA hypomethylation.
- Cytosine methylation and the ecology of intragenomic parasites.
Cited by
- Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.
- Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases
- DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair
- Upregulation of galectin-7 in murine lymphoma cells is associated with progression toward an aggressive phenotype
- Monoclonal antibody against dnmt1 arrests the cell division of xenopus early-stage embryos.
- Expression of PEA3/E1AF/ETV4, an Ets-related transcription factor, in breast tumors: positive links to MMP2, NRG1 and CGB expression.
- Structural and functional preservation of specific sequences of DNA and mRNA in apoptotic bodies from ES cells
- Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer
- Using nutrigenomics to evaluate apoptosis as a preemptive target in cancer prevention.
- Epigenetic Drug Discovery
- The Epigenetic Paradox of Pluripotent ES Cells.
- Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
- Histone-modifier genes regulate morphogenesis of "Candida albicans"
- Aging Effects on Optic Nerve Neurodegeneration
- XENOESTROGEN-SPECIFIC MECHANISMS OF DEVELOPMENTAL REPROGRAMMING CORRELATE WITH GENE EXPRESSION AND TUMOR DEVELOPMENT
- An Improved Antibody-based Method to Detect Whole Genome Cytosine Methylation in Mouse Embryonic Fibroblasts
- Treatment of Nuclear-Donor Cells or Cloned Zygotes with Chromatin-Modifying Agents Increases Histone Acetylation But Does Not Improve Full-Term Development of Cloned Cattle
- Epigenetic regulation of pluripotency.
- Los elementos genéticos móviles en la célula tumoral: el despertar de un gigante
- The Effects of Phytohormones and 5-Azacytidine on Apoptosis in Etiolated Wheat Seedlings
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