The fundamental role of epigenetic events in cancer
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Summary
This review discusses patterns of DNA methylation and chromatin structure in neoplasia and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.
- Type
- review
- Published
- 2002-06-01
- Cited by
- 5,845
- References
- 117
- OpenAlex
- https://openalex.org/W1504303645
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2122000
Keywords
Epigenetics, Biology, DNA methylation, Chromatin, Cancer epigenetics
References
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- Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia
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- p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing.
- Science and society
- Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
- DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
- Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
- Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
- Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
- Cell division is required for de novo methylation of CpG islands in bladder cancer cells.
- DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
- CpG methylation is maintained in human cancer cells lacking DNMT1
- A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
- Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
- DNA methyltransferase Dnmt1 associates with histone deacetylase activity
- Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development.
- Reduced genomic 5-methylcytosine content in human colonic neoplasia.
- Cancer-epigenetics comes of age
- Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
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- Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer
- Ontogeny of a Demethylation Domain and Its Relationship to Activation of Tissue-Specific Transcription1
- Hypermethylation of tumor suppressor genes (p16INK4A, p14ARF and APC) in adenocarcinomas of the upper gastrointestinal tract
- CpG island methylator phenotype in cancer
- Identification of a three-gene expression signature of poor-prognosis breast carcinoma
- Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors.
- Folate and its preventive potential in colorectal carcinogenesis. How strong is the biological and epidemiological evidence?
- Coordinated Changes in DNA Methylation and Histone Modifications Regulate Silencing/Derepression of Luteinizing Hormone Receptor Gene Transcription
- Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1