PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
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Summary
An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle.
- Type
- article
- Published
- 2003-07-01
- Cited by
- 8,384
- References
- 36
- OpenAlex
- https://openalex.org/W2123106337
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13940856
Keywords
Biology, Gene, DNA microarray, Gene expression profiling, Gene expression
References
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- Large-scale analysis of the human and mouse transcriptomes
- Metabolic Consequences of a Family History of NIDDM (The Botnia Study): Evidence for Sex-Specific Parental Effects
- A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes
- Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
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- Molecular interactions of Salmonella with the host epithelium in the presence of commensals
- Molecular pathogenesis of MALT lymphoma
- FM-GA and CM-GA for gene microarray analysis.
- Designing, performing, and interpreting a microarray-based gene expression study.
- Genetics of Diabetes
- Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.
- Genetic Basis of Atherosclerosis: Part I: New Genes and Pathways
- Inferring pathways from gene lists using a literature-derived network of biological relationships
- Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice.
- Microarray Data Analysis: From Hypotheses to Conclusions Using Gene Expression Data
- Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients.
- Type 2 diabetes: principles of pathogenesis and therapy
- Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population
- Protein Interaction Networks
- A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
- Defining aggressive prostate cancer using a 12-gene model.
- Global Transcriptome Analysis of Genetically Identified Neurons in the Adult Cortex
- Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
- Impaired Fat Oxidation After a Single High-Fat Meal in Insulin-Sensitive Nondiabetic Individuals With a Family History of Type 2 Diabetes
- Fine needle aspiration coupled with real-time PCR: a painless methodology to study adaptive functional changes in skeletal muscle.
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