Impaired Fat Oxidation After a Single High-Fat Meal in Insulin-Sensitive Nondiabetic Individuals With a Family History of Type 2 Diabetes
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Summary
An impaired ability to increase fatty acid oxidation precedes the development of insulin resistance in genetically susceptible individuals and PGC1α and FAT/CD36 are likely candidates in mediating this response.
- Type
- article
- Published
- 2007-08-01
- Cited by
- 74
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W17456847
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:130786
Keywords
Environmental science
References
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- Intramyocellular lipid content and molecular adaptations in response to a 1-week high-fat diet.
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- Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients
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- Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.
- The NR4A subgroup: immediate early response genes with pleiotropic physiological roles
- Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids
- Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
- Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.
- Intramyocellular lipid is not significantly increased in healthy young insulin resistant first-degree relatives of diabetic subjects.
Cited by
- Regulation and function of adiponectin receptors in skeletal muscle.
- In vivo and in vitro regulation of skeletal muscle lipid metabolism
- Room calorimetry as a method of measuring metabolic flexibility
- Metabolomic analysis reveals decreased skeletal muscle amino acid content and altered fatty acid handling in obese humans
- Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls.
- Pregnancy induces molecular alterations reflecting impaired insulin control over glucose oxidative pathways that only in women with a family history of Type 2 diabetes last beyond pregnancy
- Effect of contrasted levels of habitual physical activity on metabolic flexibility.
- Association study of CD36 single nucleotide polymorphisms with essential hypertension in the Northeastern Han Chinese.
- Role of dietary carbohydrates and macronutrients in the pathogenesis of nonalcoholic fatty liver disease
- Effects of a meal rich in medium-chain saturated fat on postprandial lipemia in relatives of type 2 diabetics.
- Insulin, Aging, and the Brain: Mechanisms and Implications
- Skeletal Muscle Insulin Resistance: The Interplay of Local Lipid Excess and Mitochondrial Dysfunction
- Change of myocardium FAT/CD36 expression in rats with type 2 diabete and its influence on fatty acid metabolism: Change of myocardium FAT/CD36 expression in rats with type 2 diabete and its influence on fatty acid metabolism
- Acute effects of monounsaturated fat on postprandial lipemia and gene expression in first-degree relatives of subjects with type 2 diabetes
- Increased Postprandial Nonesterified Fatty Acid Appearance and Oxidation in Type 2 Diabetes Is Not Fully Established in Offspring of Diabetic Subjects
- A family history of type 2 diabetes increases risk factors associated with overfeeding
- Effects of xylitol on metabolic parameters and visceral fat accumulation
- MATERNAL OBESITY AND OXIDATIVE STRESS IN THE FETUS: MECHANISMS UNDERLYING EARLY LIFE SHIFTS IN SKELETAL MUSCLE METABOLISM
- PGC-1α Regulation of Mitochondrial Degeneration in Experimental Diabetic Neuropathy
- Paradoxically Low Levels of Total and HMW Adiponectin in Relation to Metabolic Parameters in a Tongan Population
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