A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas
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Summary
A functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD) is shown and the link between hypoxia signals (via VHL) and mitochondrial signals ( via SDH) is mediated by HIF1α.
- Type
- article
- Published
- 2005-07-01
- Cited by
- 427
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W16103922
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18260235
Keywords
Computer science
References
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- Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice
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- HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
- Signaling through Ras Is Essential for retOncogene-induced Cell Differentiation in PC12 Cells*
- Analysis of the SDHD gene, the susceptibility gene for familial paraganglioma syndrome (PGL1), in pheochromocytomas.
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- Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
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- Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice
Cited by
- Oxygen-sensing in tumors
- Clinically guided genetic screening in a large cohort of italian patients with pheochromocytomas and/or functional or nonfunctional paragangliomas.
- Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma
- Murine Models and Cell Lines for the Investigation of Pheochromocytoma: Applications for Future Therapies?
- Respiratory chain complex II as general sensor for apoptosis.
- Oncometabolites‐driven tumorigenesis: From genetics to targeted therapy
- 15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma.
- New HIF2α inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas.
- Role of hypoxia and HIF2α in development of the sympathoadrenal cell lineage and chromaffin cell tumours with distinct catecholamine phenotypic features
- Changing paradigms in the treatment of malignant pheochromocytoma.
- Effects of site-directed mutations in Escherichia coli succinate dehydrogenase on the enzyme activity and production of superoxide radicals.
- Pheochromocytoma: Gasping for Air
- Charting the Genetic Landscape and Clonal Architectures of Pheochromocytoma
- From Nf1 to Sdhb knockout: Successes and failures in the quest for animal models of pheochromocytoma.
- Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics
- From chromaffin cells to Phaeochromocytoma: insight into the sympathoadrenal cell lineage
- The role of HIF-1 in hypoxic response in the skeletal muscle.
- Novel hereditary forms of pheochromocytomas and paragangliomas.
- MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging
- Three autocrine feedback loops determine HIF1α expression in chronic hypoxia
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