A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas

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Summary

A functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD) is shown and the link between hypoxia signals (via VHL) and mitochondrial signals ( via SDH) is mediated by HIF1α.

Type
article
Published
2005-07-01
Cited by
427
References
45
Access
Open access

Keywords

Computer science

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