The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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Summary

The function of the fifth adaptor, SARM, has been revealed, which negatively regulates TRIF, and it is shown that it acts as a bridging adaptor in the initiation of TLR signalling.

Type
review
Published
2007-05-01
Cited by
2,829
References
118
Access
Open access

Keywords

TRIF, Signal transducing adaptor protein, Interferon regulatory factors, TLR2, Cell biology

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