The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
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Summary
The function of the fifth adaptor, SARM, has been revealed, which negatively regulates TRIF, and it is shown that it acts as a bridging adaptor in the initiation of TLR signalling.
- Type
- review
- Published
- 2007-05-01
- Cited by
- 2,829
- References
- 118
- Access
- Open access
- OpenAlex
- https://openalex.org/W2115185894
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5872298
Keywords
TRIF, Signal transducing adaptor protein, Interferon regulatory factors, TLR2, Cell biology
References
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- Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance1
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Cited by
- Mechanism of natural killer cell mediated T cell cycle arrest during human parainfluenza virus type 3 infection
- Early events in the recognition of danger signals after tissue injury
- Intracellular DNA sensors in immunity.
- The Critical Role of Toll-Like Receptor (TLR) 4 in Alcoholic Liver Disease Is Independent of the Common TLR Adapter MyD88
- Viral evasion and subversion of pattern-recognition receptor signalling
- Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis*
- Full‐length sequence and expression analysis of a myeloid differentiation factor 88 (MyD88) in half‐smooth tongue sole Cynoglossus semilaevis
- Transcriptional analysis of Toll-like receptors expression in M cells.
- Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis
- TRAF6 knockdown promotes survival and inhibits inflammatory response to lipopolysaccharides in rat primary renal proximal tubule cells
- Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models
- The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway
- Inhaled innate immune ligands to prevent pneumonia
- Cell biology and immunology of Listeria monocytogenes infections: novel insights
- Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
- Identification of interleukin‐1 receptor‐associated kinase 1 as a critical component that induces post‐transcriptional activation of IκB‐ζ
- Differential Cell Sensitivity between OTA and LPS upon Releasing TNF-α
- Cross‐talk between toll‐like receptor 4 (TLR4) and proteinase‐activated receptor 2 (PAR2) is involved in vascular function
- Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins
- Anti-Inflammatory Activity of Odina wodier Roxb, an Indian Folk Remedy, through Inhibition of Toll-Like Receptor 4 Signaling Pathway
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