MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
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Summary
The dependence of Th2 responses on MyD88 is governed by the initial route of antigen exposure; this demonstrates what the authors believe are novel site-specific innate mechanisms for control of adaptive Th2 immunity.
- Type
- article
- Published
- 2005-02-01
- Cited by
- 254
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W1968245616
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6504298
Keywords
Acquired immune system, Immunology, Innate immune system, TLR4, Immunity
References
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- Characterization of a murine model of allergic pulmonary inflammation.
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- Toll-like receptors.
- Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
- In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.
- Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
- Aerosol-induced Immunoglobulin (Ig)-E Unresponsiveness to Ovalbumin Does Not Require CD8+ or T Cell Receptor (TCR)-γ/δ+ T Cells or Interferon (IFN)-γ in a Murine Model of Allergen Sensitization
- Stimulation of Langerhans cell migration by tumor necrosis factor alpha (TNF-alpha).
- Regulation of dendritic cell function through toll-like receptors.
- An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.
Cited by
- Dendritic cells and airway epithelial cells at the interface between innate and adaptive immune responses
- DC-derived TSLP promotes Th2 polarization in LPS-primed allergic airway inflammation
- Role of iron and oxidative stress in the exacerbation of allergic inflammation in murine lungs caused by urban particulate matter <2.5 μm and desert dust
- A Component-Resolved Therapeutic Vaccine for Cockroach Allergy Made of Per a 9 and Transforming Growth Factor-β Homologue, an Immunosuppressive Protein of Brugia malayi
- Comparison of the Abilities of IL-10- and Retinoic Acid- Differentiated Dendritic Cells to Induce Allergen Tolerance in a Mouse Model of Asthma
- Pulmonary innate immune modulation in the pathogenesis of allergic asthma
- Novel Mechanisms In Dendritic Cells That Promote Th2 and Th17 But Not Th1 Responses In The Lung
- Toll-like receptors in CNS parasitic infections.
- Stem Cell and Biological Interventions to treat Allergic Airway Disease
- Funktionelle Charakterisierung MyD88-abhängiger Signalwege bei der atopischen Dermatitis im Mausmodell
- Chimiokines et interaction entre l'immunité innée et adaptative dans l'asthme allergique : implication des cellules dendritiques et du récepteur NOD1
- Innate immune activation in experimental autoimmune myocarditis
- Use and limitations of alum-based models of allergy
- CARMA3 is Critical for the Initiation of Allergic Airway Inflammation
- Dendritic Cell Modulation by Mast Cells Controls the Th1/Th2 Balance in Responding T Cells1
- Translational Mini‐Review Series on Toll‐like Receptors: Toll‐like receptor ligands as novel pharmaceuticals for allergic disorders
- Dishing the dirt on asthma: What we can learn from poor hygiene
- Efeito da exposição precoce ao poluente 1,2-NQ sobre a resposta imune inata e adquirida de camundongos: papel dos receptores toll.
- Neonatal innate immunity - A translational perspective
- Toll‐like receptor and tumour necrosis factor dependent endotoxin‐induced acute lung injury
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