Suppression of TRIF-dependent signaling pathway of toll-like receptors by (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine.
Explore this paper's citation graph
Summary
The results suggest that NVPP can modulate TRIF-dependent signaling pathways of TLRs, potentially resulting in effective therapeutics for chronic inflammatory diseases.
- Type
- article
- Published
- 2013-12-05
- Cited by
- 2
- References
- 26
- OpenAlex
- https://openalex.org/W2033645920
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42711681
Keywords
TRIF, IRF3, Interferon regulatory factors, Signal transduction, Toll-like receptor
References
- A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex1
- Inhibition of homodimerization of Toll-like receptor 4 by curcumin.
- Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1.
- Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol
- Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea.
- Multiple signaling pathways leading to the activation of interferon regulatory factor 3.
- Pathogen recognition and innate immunity.
- The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
- Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists.
- Scope and Limitations of the T-Reaction Employing Some Functionalized C—H Acids and Naturally Occurring Secondary Amines.
- Suppression of inducible nitric oxide synthase expression induced by Toll-like receptor agonists by (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine.
- IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
- When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.
- Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes1
- TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity.
- The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
- Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization.
- Suppression of Toll-like receptor 2 or 4 agonist-induced cyclooxygenase-2 expression by 4-oxo-4-(2-oxo-oxazolidin-3-yl)-but-2-enoic acid ethyl ester.
- IKKε and TBK1 are essential components of the IRF3 signaling pathway
Cited by
Related papers
- Viral recognition and type I interferon production by Toll-like receptor and an RNA helicase, RIG-I
- Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
- IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
- Inflammatory response to Porphyromonas gingivalis partially requires interferon regulatory factor (IRF) 3
- Costunolide inhibits interferon regulatory factor 3 activation induced by lipopolysaccharide and polyinosinic-polycytidylic acid
- Japanese encephalitis virus NS4B inhibits interferon beta production by targeting TLR3 and TRIF.
- Eupatorium japonicum extract regulates inflammation through suppression of the TRIF-dependent signaling pathway of toll-like receptors
- High-throughput microfluidic platform for culture of 3D-kidney tissue models
- Biologic functions of Toll-like receptor 3 for virus infection and cell apoptosis