IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.

Keywords

Signal transduction, Cell biology, Kinase, Receptor, Biology

References

• Molecular characterization and modular analysis of human MyD88.Gary Hardiman, Fernando L. Rock, Shankar Balasubramanian — 1996
• Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.K. A. Lord, Barbara Hoffman‐Liebermann, Dan A. Liebermann — 1990
• A human homologue of the Drosophila Toll protein signals activation of adaptive immunityRuslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway — 1997
• The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family 1Timothy P. Bonnert, K.E. Garka, Patricia Parnet — 1997
• The death domain: a module shared by proteins with diverse cellular functions.Elena Feinstein — 1995
• Cytosolic domain of the type I interleukin-1 receptor spontaneously recruits signaling molecules to activate a proinflammatory gene.Rashmi Singh, Shuang Huang, T Guth — 1997
• Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.Norman W. Freshney, Lesley Rawlinson, François Guesdon — 1994
• cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily.John E. Sims, Caril J. March, David Cosman — 1988
• FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.Arul M. Chinnaiyan, Karen O’Rourke, Muneesh Tewari — 1995
• Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family.Dan Hultmark — 1994
• Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymeraseMuneesh Tewari, Long T. Quan, Karen O’Rourke — 1995
• The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)*Holger Wesche, Christian Korherr, Michael Kracht — 1997
• The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidanceKay Hofmann, J Tschopp — 1995
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.Steven K. Hanks, Anne Marie Quinn, Tony Hunter — 1988
• Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryoJörg Großhans, Andreas Bergmann, Pascal Haffter — 1994
• RAIDD is a new 'death' adaptor moleculeHangjun Duan, Vishva M. Dixit — 1997
• MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1Nikolay Malinin, Mark Boldin, A. V. Kovalenko — 1997
• A critical role for interleukin‐1 receptor accessory protein in interleukin‐1 signalingChristian Korherr, Robert Hofmeister, Holger Wesche — 1997
• Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex (*)Scott Greenfeder, Perla Nunes, Lia Kwee — 1995
• IRAK: A Kinase Associated with the Interleukin-1 ReceptorZhaodan Cao, William J. Henzel, Xiong Gao — 1996

Cited by

• Airway epithelium and apoptosisHarumi Jyonouchi — 1999
• Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6R Mills — 2000
• Toll‐like receptors: molecular mechanisms of the mammalian immune responseSebastian Liem — 2000
• MAP kinases in the immune response.施春霞 — 2002
• Toll-like receptor signaling in sepsis康博 梶原, 紘一 大崎 — 2003
• SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide.Luigi Pati — 2003
• NF-κB translocation prevents host cell death after low-dose challenge by Legionella pneumophilaElvino Silvestri, Linnea Passaler, Maurizio Silvestri — 2006
• Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA from Zhikong scallop Chlamys farreri.Paul Bracken, Ian Bremmer, David Gordon — 2007
• Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages聡洋 石村, 悟郎 高田, 真司 大北 — 2007
• Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis*一郎 阪本 — 2009
• Mecanismos de transducciÓn del lipopolisacáridoAlmudena Bermejo, Juan Duarte — 2003
• The same and not the same: heterogeneous functional activation of prostate tumor cells by TLR ligationErina Ariantini — 2014
• Recent advances in the development of immunostimulatory oligonucleotides.Eugen Uhlmann, Joerg Vollmer — 2003
• LMP1 TRAFficking activates growth and survival pathways.Vishal Soni, Ellen Cahir-McFarland, Elliott Kieff — 2007
• Retroviral mutagenesis in a newly developed myc transgenic mouse model of human B cell and plasma cell neoplasiaSamuel Lifton — 2013
• The Host Immune Response to Streptococcus pneumoniae: Bridging Innate and Adaptive ImmunityKatherine S. Lee — 2006
• IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A DissertationThomas B. Thornley — 2006
• Characterisation of viral proteins that inhibit Toll-like receptor signal transduction.Julianne Stack, Andrew Bowie — 2009
• The forward genetic dissection of afferent innate immunity.Bruce Beutler, Eva Marie Y. Moresco — 2008
• Rôle fonctionnel du Toll-Like Receptor 4 exprimé par les plaquettes sanguines en tant que cellules inflammatoires de l'immunitéJulien Berthet — 2010

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