Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
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Summary
It is found that MyD88 and TRIF have mainly evolved under purifying selection, suggesting that their role in the early stages of signal transduction is essential and nonredundant for host survival.
- Type
- article
- Published
- 2011-06-09
- Cited by
- 50
- References
- 80
- Access
- Open access
- OpenAlex
- https://openalex.org/W21659570
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45196147
Keywords
Computer science
References
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- Genes of innate immunity and their significance in evolutionary ecology of free livings rodents
- Genomic Approaches to Dissect Innate Immune Pathways
- Human genome variability, natural selection and infectious diseases.
- Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE)
- Identification, expression pattern and functional characterization of As-MyD88 in bacteria challenge and during different developmental stages of Artemia sinica.
- The Red Queen's long race: human adaptation to pathogen pressure.
- Critical role of myeloid differentiation factor 88 in necrotizing enterocolitis
- Population genetic tools to dissect innate immunity in humans
- A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses
- Inborn errors of anti-viral interferon immunity in humans
- Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K
- Phylogeny of Toll-Like Receptor Signaling: Adapting the Innate Response
- Evolution of vertebrate immunity.
- The Genetics of Innate Immunity Sensors and Human Disease
- Immunology taught by human genetics.
- Genetic variation in Toll-like receptors and disease susceptibility
- Reproduction and immunity-driven natural selection in the human WFDC locus.
- Towards a Liquid Self: How Time, Geography, and Life Experiences Reshape the Biological Identity
- Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes.
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