Systemic LPS protects the brain from ischemic injury by reprogramming the brain's response to stroke: a critical role for IRF3
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Summary
These studies constitute the first demonstration of the neuroprotective capacity of TRIF/IRF3 signaling and suggest that interferon-stimulated genes, whether induced by IFNβ or by enhanced TLR signaling to IRF3, are a potent means of protecting the brain against ischemic damage.
- Type
- article
- Published
- 2009-08-05
- Cited by
- 222
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021008015
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17034626
Keywords
TRIF, IRF3, Neuroprotection, Interferon regulatory factors, TLR4
References
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Cited by
- Low-dose lipopolysaccharide injection prior to subarachnoid hemorrhage modulates delayed deterioration associated with vasospasm in subarachnoid hemorrhage
- Pharmacological preconditioning with GYKI-52466: a prophylactic approach to neuroprotection against ischaemic stroke in the rat
- LPS-Primed Release of HMGB-1 from Cortical Astrocytes is Modulated Through PI3K/AKT Pathway
- Repetitive Acute Intermittent Hypoxia Does Not Promote Generalized Inflammatory Gene Expression in the Rat CNS
- Studies on poly-ICLC treatment as a potent neuroprotective therapy against ischemic brain injury
- The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases
- Lipopolysaccharide-Induced Preconditioning Attenuates Apoptosis and Differentially Regulates TLR4 and TLR7 Gene Expression after Ischemia in the Preterm Ovine Fetal Brain
- Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury
- Novel Role for the Innate Immune Receptor Toll-Like Receptor 4 (TLR4) in the Regulation of the Wnt Signaling Pathway and Photoreceptor Apoptosis
- Cytokines: their role in stroke and potential use as biomarkers and therapeutic targets.
- The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review.
- DEFINING THE PLAYERS IN HIGHER-ORDER NETWORKS: PREDICTIVE MODELING FOR REVERSE ENGINEERING FUNCTIONAL INFLUENCE NETWORKS
- β‐Arrestin 2 regulates toll‐like receptor 4‐mediated apoptotic signalling through glycogen synthase kinase‐3β
- The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
- Models of progressive neurological dysfunction originating early in life
- Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke.
- Biological role of Toll-like receptor-4 in the brain.
- Microglial activation in stroke: Therapeutic targets
- Toll-like receptor tolerance as a mechanism for neuroprotection
- Disruption of downstream MyD88 or TRIF Toll-like receptor Signaling does not protect against cerebral ischemia
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