The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.
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Summary
A product of the mdm-2 oncogene forms a tight complex with the p53 protein, and the mDM-2oncogene can inhibit p53-mediated transactivation.
- Type
- article
- Published
- 1992-06-26
- Cited by
- 3,284
- References
- 53
- OpenAlex
- https://openalex.org/W2099907467
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22594319
Keywords
Transactivation, Biology, Gene product, Phosphoprotein, Molecular biology
References
- Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
- The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.
- p53 is associated with p34cdc2 in transformed cells.
- Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.
- Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
- Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
- Multistage Friend erythroleukemia: independent origin of tumor clones with normal or rearranged p53 cellular oncogenes
- Energy requirement for degradation of tumor-associated protein p53
- Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex
- Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny
- Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
- Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein
- Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP
- Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
- A new technique for the assay of infectivity of human adenovirus 5 DNA.
- Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.
- Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein.
- Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
- Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
- Wild-type p53 can inhibit oncogene-mediated focus formation.
Cited by
- The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin.
- Investigation of the intrinsic mechanism of drug resistance in multiple myeloma
- MDM2 overexpression, activation of signaling networks, and cell proliferation.
- Immunohistochemical detection of p53 protein in mammary carcinoma: an important new independent indicator of prognosis?
- Lymphocyte death, p53, and the problem of the "undead" cell.
- WAF1/CIP1 protein expression in human breast tumors
- Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
- Disruption of actin microfilaments by cytochalasin D leads to activation of p53
- The influence of p53 and associated factors on the outcome of patients with oral squamous cell carcinoma
- Aberrant expression of the cell cycle associated proteins TP53, MDM2, p21, p27, cdk4, cyclin D1, RB, and EGFR in cervical carcinomas.
- The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF
- Regulation of p53 stability
- Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features
- Regulation of p53 function.
- Molecular evolution of the p53 network in reptiles
- Molecular biology of gliomas
- Modulation of p53 expression and its role in the conversion to a fully immortalized chicken embryo fibroblast line
- A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
- MDM2 interacts with and downregulates a sarcomeric protein, TCAP.
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.
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