Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
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Summary
The results provide clear immunological evidence for the specific association of a single heat shock protein, hsc70, with p53 in p53-plus-ras-transformed cell lines and suggest that the p 53-hsc70 protein complex could have functional significance in these transformed cells.
- Type
- article
- Published
- 1987-08-01
- Cited by
- 236
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W1952836109
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19802043
Keywords
Biology, HSPA4, Molecular biology, HSPA14, Heat shock protein
References
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- The 70‐kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.
- Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.
- Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.
- Energy requirement for degradation of tumor-associated protein p53
- Overproduction of protein p53 contributes to simian virus 40-mediated transformation
- Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex
- Quantitation of a 55K cellular protein: similar amount and instability in normal and malignant mouse cells
- Expression of the mouse p53 cellular tumor antigen in monkey cells
- Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.
- Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
- Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
- Cellular and biochemical events in mammalian cells during and after recovery from physiological stress
- Uncoating ATPase is a member of the 70 kilodalton family of stress proteins.
- Speculations on the functions of the major heat shock and glucose-regulated proteins.
- Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.
- Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.
Cited by
- Nuclear colocalization of c-myc protein and hsp70 in cells transfected with human wild-type and mutant c-myc genes.
- A comparison of the properties of human p53 mutant alleles.
- C/EBPalpha regulation of the growth-arrest-associated gene gadd45
- Normal and malignant growth control by p53.
- Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer.
- Interactions between SV40 and cellular oncogenes in the transformation of primary rat cells.
- Immunhistorischer Nachweis vom p53 Tumorsuppressorprotein bei periorbitalen Talgdrüsenkarzinomen
- Genetic aspects of cancer.
- The role of anti-p53-autoantibodies in pancreatic disorders
- Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines.
- Chaperones and matchmakers: inhibitors and stimulators of protein phosphorylation.
- Dissection of the T antigen/mouse p53 complex and its inhibitory effects on viral origin-directed DNA replication in vivo and in vitro.
- p53: Onco - or Anti-Onco - Gene? A Critical Review
- Stress Proteins
- Protein interaction of retinoblastoma gene product pRb110 with M(r) 73,000 heat shock cognate protein.
- Tumor suppressor p53 mutations and breast cancer: a critical analysis.
- Contribution of the DNA binding domain of p53 to regulation of its stability
- An early event in murine cytomegalovirus replication inhibits presentation of cellular antigens to cytotoxic T lymphocytes
- Multiple modes of Mdmx regulation affect p53 activation
- Mutation of the serine 312 phosphorylation site does not alter the ability of mouse p53 to inhibit simian virus 40 DNA replication in vivo
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