Identification of structural domains affecting transactivation potential of Nm23.
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Summary
Transactivation potential of Nm23 is related to NDP kinase activity but not to metastasis suppressor activity, suggesting that NPD kinase active-site histidine is required.
- Type
- article
- Published
- 2001-12-07
- Cited by
- 13
- References
- 31
- OpenAlex
- https://openalex.org/W2015076784
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25404429
Keywords
Transactivation, Amino acid, Suppressor, Biochemistry, Chemistry
References
- Inhibitory activity of nm23-H1 on invasion and colonization of human prostate carcinoma cells is not mediated by its NDP kinase activity.
- Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.
- A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential.
- A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme.
- Experiments in molecular genetics
- A new human nm23 homologue (nm23‐H5) specifically expressed in testis germinal cells 1
- Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.
- nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13
- Effect of aPMR1 disruption on the processing of heterologous glycoproteins secreted in the yeastSaccharomyces cerevisiae
- Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila.
- A novel human nucleoside diphosphate (NDP) kinase, Nm23‐H6, localizes in mitochondria and affects cytokinesis
- Site-directed Mutation of Nm23-H1
- Site-directed Mutagenesis of nm23-H1
- Evidence for a novel gene associated with low tumor metastatic potential.
- Nm23/PuF Does Not Directly Stimulate Transcription through the CT Element in Vivo *
- Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.
- nm23-H1 mutation in neuroblastoma
- Expression of a catalytically inactive H118Y mutant of nm23‐H2 suppresses the metastatic potential of line IV Cl 1 human melanoma cells
- nm23: Unraveling its biological function in cell differentiation
- Phosphorylation of ATP-Citrate Lyase by Nucleoside Diphosphate Kinase (*)
Cited by
- Multiple Biochemical Activities of NM23/NDP Kinase in Gene Regulation
- Basic and Translational Advances in Cancer Metastasis: Nm23
- Inhibition of signal transduction by the nm23 metastasis suppressor: Possible mechanisms
- Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway*
- Nucleoside diphosphate kinase/Nm23 and Epstein–Barr virus
- Translational approaches using metastasis suppressor genes
- Nm23-H1 can induce cell cycle arrest and apoptosis in B cells
- Histidine kinases and histidine phosphorylated proteins in mammalian cell biology, signal transduction and cancer.
- NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway.
- Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2.
- 具有不同酶活性并可抵抗特异shRNA降解的nm23-H1真核表达载体的构建和表达
- NM23/NDPK proteins in transcription regulatory functions and chromatin modulation: emerging trends
- Nm23 as a Metastasis Inhibitor
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