Identification of constitutive and steroid-dependent transactivation domains in the mouse oestrogen receptor.
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Summary
The analysis of receptor deletion mutants has demonstrated that these two functions are not entirely coincident, and the differences in oestrogen requirement for the activity of the two transactivation domains may account for the partial agonist activity of certain antihormones.
- Type
- article
- Published
- 1989-01-01
- Cited by
- 66
- References
- 35
- OpenAlex
- https://openalex.org/W2049911257
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19677632
Keywords
Transactivation, Receptor, Agonist, Biology, Cell biology
References
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- Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication
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- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
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- Multiple and cooperative trans-activation domains of the human glucocorticoid receptor.
- Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA
- Gene regulation by steroid hormones.
- Acid blobs and negative noodles
- The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function.
- Glucocorticoid receptor mutants that define a small region sufficient for enhancer activation.
- A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene.
Cited by
- Activated oncogenes and putative tumor suppressor genes involved in human breast cancers.
- Estrogen Receptors α and β Form Heterodimers on DNA*
- Chromatin-remodeling complexes involved in gene activation by the glucocorticoid receptor.
- Charakterisierung des murinen Germ Cell Nuclear Factor (GCNF)-Promotors
- Structure and function of estrogen receptors.
- Production and characterization of monoclonal antibodies recognising defined regions of the human oestrogen receptor.
- An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol.
- Evolution of the gelsolin family of actin‐binding proteins as novel transcriptional coactivators
- Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo.
- An Antiestrogen-responsive Estrogen Receptor-α Mutant (D351Y) Shows Weak AF-2 Activity in the Presence of Tamoxifen*
- Antiestrogen-liganded estrogen receptor interaction with estrogen responsive element DNA in vitro.
- Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation.
- A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast.
- Estrogen Receptor Isoform-specific Regulation of the Retinoblastoma-binding Protein 1 (RBBP1) Gene
- Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells (*)
- Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.
- Identification of estrogen receptor alpha gene polymorphisms by SSCP and its effect on reproductive traits in Japanese flounder (Paralichthys olivaceus).
- Mechanisms of action of steroid receptors in the regulation of gene transcription.
- Signaling by estrogens
- Insulin-like growth factors control the regulation of oestrogen and progesterone receptor expression by oestrogens.
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