Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
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Summary
It is demonstrated that complex formation between mutant p53 and hsc70 is not required for p53-mediated transformation, but rather it facilitates this function, perhaps by ensuring sequestration of the endogenous wild-type p53 protein.
- Type
- article
- Published
- 1990-12-01
- Cited by
- 416
- References
- 61
- OpenAlex
- https://openalex.org/W1564956131
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21388273
Keywords
Mutant, Biology, Heat shock protein, Oncogene, Molecular biology
References
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- Meth A fibrosarcoma cells express two transforming mutant p53 species.
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- Energy requirement for degradation of tumor-associated protein p53
- Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53
- Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex
- Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
- Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
- Expression of the mouse p53 cellular tumor antigen in monkey cells
- Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
- Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines
- High-efficiency transformation of mammalian cells by plasmid DNA.
- A new technique for the assay of infectivity of human adenovirus 5 DNA.
- The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses.
- Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
- Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells
- Rearrangement of the p53 gene in human osteogenic sarcomas.
Cited by
- The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin.
- The p53 tumor‐suppressor gene and ras oncogene mutations in oral squamous‐cell carcinoma
- A comparison of the properties of human p53 mutant alleles.
- High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
- Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas.
- Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes
- Predicting Neoplastic Progression in Barrett's Esophagus
- Normal and malignant growth control by p53.
- p53 expression in human breast cancer.
- Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions*
- Novel miRNA-mRNA interactions conserved in essential cancer pathways
- Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinoma cells to induce a conversion of a nontumorigenic to a tumorigenic phenotype
- Molecular genetics of human malignant melanoma.
- p53 Protein Accumulation Is a Specific Marker of Malignant Potential in Barrett's Metaplasia
- Expression patterns of the p53 tumor suppressor gene and the mdm2 proto-oncogene in human meningiomas
- Association of p53 and WAF1 expression with apoptosis in diffuse alveolar damage.
- The p53 tumor-suppressor gene in human breast cancer.
- Curcumin Is an In Vivo Inhibitor of Angiogenesis
- Oncogenes and tumor suppressor genes.
- Cooperation of p53 mutations with other oncogenic alterations in cancer.
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