Four faces of cellular senescence
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Summary
The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks.
- Type
- review
- Published
- 2011-02-21
- Cited by
- 1,989
- References
- 139
- Access
- Open access
- OpenAlex
- https://openalex.org/W2077450385
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6933892
Keywords
Senescence, Biology, Carcinogenesis, Cellular senescence, Cell biology
References
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
- TIN2 Mediates Functions of TRF2 at Human Telomeres*
- The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms.
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
- Senescence of activated stellate cells limits liver fibrosis
- Cellular lifespan and senescence signaling in embryonic stem cells
- Cancer and ageing: a nexus at several levels
- Mutation of the mouse klotho gene leads to a syndrome resembling ageing
- Senescence of human fibroblasts induced by oncogenic Raf.
- Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.
- Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas.
- A DNA damage checkpoint response in telomere-initiated senescence
- Cellular senescence: when bad things happen to good cells
- DNA damage foci at dysfunctional telomeres.
- The hallmarks of cancer
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
- Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
Cited by
- Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence
- The senescence arrest program and the cell cycle.
- Aging Processes and the Development of Osteoarthritis
- Aging increases CCN1 expression leading to muscle senescence.
- Stromal-initiated changes in the bone promote metastatic niche development
- 4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines
- Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer*
- Amniotic Epithelial Cells: A New Tool to Combat Aging and Age-Related Diseases?
- Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
- The cell cycle regulator protein P16 and the cellular senescence of dental follicle cells
- Long intergenic non‑coding RNA‑p21 mediates cardiac senescence via the Wnt/β‑catenin signaling pathway in doxorubicin-induced cardiotoxicity.
- Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
- Impact of physical activity on immune function and inflammation in the elderly
- ANGIOMOTIN IS A NOVEL CADHERIN-11 INTERACTING PROTEIN THAT MEDIATES MIGRATION IN PROSTATE CANCER CELLS
- Investigation of the effects of different cryopreservation parameters on the genome of 51/4 hpf zebrafish (Danio rerio) embryos
- Papel de las micrornas en la actividad terapéutica de las células madre mesenquimales humanas
- Cell senescence and aging in carcinogenesis and liver repopulation
- Senescence regulation by mTOR.
- The Contribution of DNA Interstrand Crosslinks to Aging
- Colorimetric Detection of Senescence-Associated β Galactosidase
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