Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

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Summary

Normal human diploid fibroblasts, TIG-1, tended to senesce after about 50 PD with a gradual decrease in sensitivity to serum, but treatment with the antisense-Rb oligomer extended life span by about 10 PD, suggesting that p53 and RB function in separate, yet complementary pathways in signal transduction to senescence.

Type
article
Published
1991-08-30
Cited by
273
References
17

Keywords

Oligomer, Biology, Molecular biology, Chemistry

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