Aging increases CCN1 expression leading to muscle senescence.
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Summary
It is concluded that in aging muscle, the circulating factor wnt-3a acts to increase CCN1 expression, prompting muscle senescence by activating cell arrest proteins.
- Type
- article
- Published
- 2014-01-01
- Cited by
- 70
- References
- 46
- OpenAlex
- https://openalex.org/W24196529
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:96687
Keywords
Computer science
References
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- Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: A model to investigate ageing?
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- Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype*
- Cyr61/CCN1 Is Regulated by Wnt/β-Catenin Signaling and Plays an Important Role in the Progression of Hepatocellular Carcinoma
- The Wnt signaling pathway: aging gracefully as a protectionist?
- CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts
- The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing
- Taking Aim at the Extracellular Matrix: CCN Proteins as Emerging Therapeutic Targets
Cited by
- MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways
- New Insights for Oxidative Stress and Diabetes Mellitus
- Cellular senescence: from physiology to pathology
- WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family
- Insights into Muscle Degeneration from Heritable Inclusion Body Myopathies
- Simvastatin Modulates Mesenchymal Stromal Cell Proliferation and Gene Expression
- Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking
- Programming Apoptosis and Autophagy with Novel Approaches for Diabetes Mellitus
- CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts.
- Bioinformatic identification of connective tissue growth factor as an osteogenic protein within skeletal muscle
- Low-frequency electrical stimulation attenuates muscle atrophy in CKD--a potential treatment strategy.
- Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease
- A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice
- Regeneration in the nervous system with erythropoietin
- Ajuga turkestanica increases Notch and Wnt signaling in aged skeletal muscle.
- CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties
- Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR
- Connective tissue growth factor (CTGF) in the human dermis through ontogenesis
- Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis.
- Picking a bone with WISP1 (CCN4): new strategies against degenerative joint disease
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