The Contribution of DNA Interstrand Crosslinks to Aging
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Summary
Collectively, these studies identified genes, environmental influences and therapeutics that impact lifespan and healthspan that strongly support the hypothesis that DNA damage can promote degenerative changes associated with aging.
- Type
- article
- Published
- 2012-08-13
- Cited by
- 0
- References
- 334
- Access
- Open access
- OpenAlex
- https://openalex.org/W133053059
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83035847
Keywords
DNA damage, DNA repair, Genome instability, DNA, Biology
References
- Endogenous DNA damage as related to cancer and aging.
- RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
- Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease.
- ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair
- Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B.
- Free radical theory of aging: history.
- Lipofuscin: detection and quantification by microscopic techniques.
- Lipid peroxidation damage to cell components.
- Reduced Purkinje cell number in essential tremor: a postmortem study.
- Progressive intercapillary glomerulosclerosis in the mouse, rat, and Chinese hamster, associated with aging and x-ray exposure.
- The Birth of Chemotherapy at Yale
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links.
- NF-κB in Aging and Disease.
- The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner
- Vitamin C exhibits pro-oxidant properties
- The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.
- The mitochondria‐targeted anti‐oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients
- Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum.
- A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.
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