Cellular senescence as a tumor-protection mechanism: the essential role of counting.
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Summary
Increasing understanding of the role of telomere shortening in the replicative aging of cultured fibroblasts now permits a re-examination of what may reasonably be called cellular senescence, and what most likely represents artifacts of the culture environment and/or specific cell-cycle control mechanisms.
- Type
- review
- Published
- 2001-02-01
- Cited by
- 344
- References
- 51
- OpenAlex
- https://openalex.org/W1999611844
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20599870
Keywords
Senescence, Biology, Telomere, Cellular senescence, Cell biology
References
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- p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
- Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
- Postnatal Growth Failure, Short Life Span, and Early Onset of Cellular Senescence and Subsequent Immortalization in Mice Lacking the Xeroderma Pigmentosum Group G Gene
- Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang*
- The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives.
- Mitotic misregulation and human aging.
- Human Endothelial Cell Life Extension by Telomerase Expression*
- Evidence for a new step in telomere maintenance.
- Telomeres shorten during ageing of human fibroblasts
- Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
- In vivo loss of telomeric repeats with age in humans.
- The serial cultivation of human diploid cell strains.
Cited by
- Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway
- Low oxygen tension alleviates oxidative damage and delays cellular senescence in G6PD-deficient cells
- From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing.
- Omeostasi dei telomeri nelle sindromi mielodisplastiche
- Telomere--the twilight to immortality.
- Telomeres and telomerase in aging, regeneration and cancer.
- Oncogenic transformation and experimental models of human cancer.
- Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation
- c-Myc, genome instability, and tumorigenesis: the devil is in the details.
- Yeast Telosome Complex: Components and Their Functions
- Télomerase et destin des tumeurs neuroblastiques
- Immortalization and transformation of human cells.
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Gene Expression Analysis of Megakaryocytes Derived from Human Umbilical Cord CD34^+ Cells by Thrombopoietin
- Implication de deux protéines de choc thermique humaines HSP70 et HSP22 dans les voies de la réparation de l'ADN : approche structurale et fonctionnelle
- Oxidative Stress and Hormesis in Evolutionary Ecology and Physiology
- Changes in DNA methylation patterns in mammals with senescence, ageing and energy restriction
- The Influence of Donor Age and In Vitro Expansion on the Proliferation and Differentiation Properties of Donor-matched Bone Marrow and Adipose-derived Mesenchymal Stem Cells: Implications for Musculoskeletal Tissue Engineering
- Assessing the effects of radiotherapy on head and neck squamous cell carcinoma using microfluidic techniques
- Telomerase and its reverse transcriptase subunit TERT : identification and oestrogenic modulation of telomerase transcription in two aquatic test species - European Purple Sea Urchin (Paracentrotus Lividus) and Rainbow Trout (Oncorhynchus Mykiss)
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