The Genetics of Type 2 Diabetes: A Realistic Appraisal in 2008
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Summary
Although substantial progress in knowledge of the genetic basis of type 2 diabetes is taking place, these new discoveries represent but a small proportion of the genetic variation underlying the susceptibility to this disorder.
- Type
- review
- Published
- 2008-12-01
- Cited by
- 115
- References
- 110
- Access
- Open access
- OpenAlex
- https://openalex.org/W2075076459
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:482589
Keywords
Type 2 diabetes, Genome-wide association study, Genetic association, Disease, Genetic architecture
References
- Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies.
- Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.
- Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.
- Variation near the hepatocyte nuclear factor (HNF)-4α gene associates with type 2 diabetes in the Danish population
- A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
- A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study
- Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study.
- Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
- Genome–wide association studies provide new insights into type 2 diabetes aetiology
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
- Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.
- A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians.
- New Susceptibility Locus for NIDDM Is Localized to Human Chromosome 20q
- A genetic link between type 2 diabetes and prostate cancer
- Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
- Genome-wide strategies for detecting multiple loci that influence complex diseases
- Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
- Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
- Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
- Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion
Cited by
- Epigenetics in Sports
- Clinically-Defined Maturity Onset Diabetes of the Young in Omanis: Absence of the common Caucasian gene mutations.
- Calpain 10 Gene Polymorphism and Its Association in Cardiomyopathy and Type 2 Diabetes
- Committee on the Prevention of Mental Disorders and Substance Abuse Among Children, Youth, and Young Adults: Research Advances and Promising Interventions
- Nutrition made clear
- Diabetes management by primary health care nurses in Auckland: A cross-sectional study
- Impact of Positive Family History and Genetic Risk Variants on the Incidence of Diabetes
- Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 diabetes mellitus: A meta-analysis
- Brd2 gene disruption causes ‘metabolically healthy’ obesity: Epigenetic and chromatin-based mechanisms that uncouple obesity from Type 2 diabetes
- Differences in the prevalence of diabetes risk-factors among First Nation, Métis and non-Aboriginal adults attending screening clinics in rural Alberta, Canada.
- Wnt signaling in pancreatic islets.
- New Genome-Wide Methods for Elucidation of Candidate Copy Number Variations (CNVs) Contributing to Alzheimer's Disease Heritability.
- Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
- Identifying module biomarker in type 2 diabetes mellitus by discriminative area of functional activity
- Type 2 diabetes mellitus in children and adolescents.
- Acute lung injury and acute respiratory distress syndrome: a genomic perspective
- Epigenetic Mechanisms in the Development of Type 2 Diabetes
- Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
- Improvements in glucose homeostasis in response to regular exercise are influenced by PPARG Pro12Ala variant: results from the HERITAGE Family Study
- Emerging concepts in the pathophysiology of type 2 diabetes mellitus.
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