Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
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Summary
The previously reported protective effect of select WFS1 alleles may be magnified by a lifestyle intervention, and these variants appear to confer an improvement in beta cell function.
- Type
- article
- Published
- 2008-03-01
- Cited by
- 74
- References
- 9
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981390105
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8158624
Keywords
Diabetes mellitus, Single-nucleotide polymorphism, Wolfram syndrome, Type 2 diabetes, Medicine
References
- Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
- Genome–wide association studies provide new insights into type 2 diabetes aetiology
- Sample-size calculations for the Cox proportional hazards regression model with nonbinary covariates.
- A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
- Common variants in WFS1 confer risk of type 2 diabetes
- Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
- Replication of the association between variants in the WFS1 gene and risk of type 2 diabetes in European populations
- Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
- Type 2 Diabetes–Associated Missense Polymorphisms KCNJ11 E23K and ABCC8 A1369S Influence Progression to Diabetes and Response to Interventions in the Diabetes Prevention Program
Cited by
- Role of WFS1 in Regulating Endoplasmic Reticulum Stress Signaling: A Dissertation
- A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.
- Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention
- Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.
- [Pharmacogenetics of insulin secretagogue antidiabetics].
- Association of Type 2 Diabetes Susceptibility Loci With One-Year Weight Loss in the Look AHEAD Clinical Trial
- Genetic variants affecting incretin sensitivity and incretin secretion
- Obesity and diabetes genes are associated with being born small for gestational age: Results from the Auckland Birthweight Collaborative study
- Wolfram Syndrome in the Japanese Population; Molecular Analysis of WFS1 Gene and Characterization of Clinical Features
- Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation
- New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms.
- Stress hypERactivation in the β-cell
- Novel biological insights emerging from genetic studies of type 2 diabetes and related metabolic traits
- The binary switch that controls the life and death decisions of ER stressed beta cells
- A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
- Pharmacogenetics of Anti-Diabetes Drugs
- Individualisierte Prävention des Typ-2-Diabetes
- Current Developments in Wolfram Syndrome
- Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
- Modifying the Diabetes Prevention Program to Adolescents in a School Setting: A Feasibility Study
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