Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
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Summary
A microsatellite within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes mellitus and is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
- Type
- article
- Published
- 2006-01-15
- Cited by
- 2,344
- References
- 31
- OpenAlex
- https://openalex.org/W1965141016
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28825825
Keywords
TCF7L2, Biology, TCF4, Genetics, Population
References
- The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.
- The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.
- Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
- A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes.
- Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
- New aspects of Wnt signaling pathways in higher vertebrates.
- Wnt Signaling: Physiology and Pathology
- Mapping Genes in Diabetes: Genetic Epidemiological Perspective
- Global and societal implications of the diabetes epidemic
- Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.
- Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans.
- Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations
- Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.
- Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
- Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
- TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta.
- Allele-sharing models: LOD scores and accurate linkage tests.
- THE INTERACTION OF SELECTION AND LINKAGE. II. OPTIMUM MODELS.
- Beta-catenin--a linchpin in colorectal carcinogenesis?
- Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Cited by
- Functional analysis of human enhancers using the zebrafish embryo
- Pharmacogenetics and future strategies in treating hyperglycaemia in diabetes.
- A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population
- The role for endoplasmic reticulum stress in diabetes mellitus.
- The association of genetic variants in Krüppel-like factor 11 and Type 2 diabetes in the Japanese population
- Prevalence of common disease-associated variants in Asian Indians
- A survey of allelic imbalance in F1 mice.
- Intron 4 a/b polymorphism of the endothelial nitric oxide synthase gene is associated with both type 1 and type 2 diabetes in a genetically homogeneous population.
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients
- Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening
- Gene–Nutrient Interactions in the Metabolic Syndrome
- A Validation Study of Type 2 Diabetes‐related Variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ Genes in one Endogamous Ethnic Group of North India
- Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
- Glucose regulation of β‐cell stress in type 2 diabetes
- Genetic determinants of hepatic steatosis in man
- Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease
- Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations
- The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes
- Cell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
- Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium.
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