Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
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Summary
The Alzheimer Disease Genetics Consortium performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1), two replication stages (stages 2 and 3), and both joint analysis and meta-analysis approaches were used.
- Type
- review
- Published
- 2011-04-03
- Cited by
- 1,890
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W1966831629
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205357506
Keywords
Genome-wide association study, Biology, Meta-analysis, Alzheimer's disease, Disease
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- Identification of Functional Variants in Alzheimer's Disease-Associated Genes
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- Can we improve care for patients with dementia?
- Genetics and epigenetics of Alzheimer's disease
- Therapeutic targeting of EPH receptors and their ligands
- The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease
- Clinical Genetics of Alzheimer's Disease
- The genetic landscape of Alzheimer disease: clinical implications and perspectives
- Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort
- New insights on the role of microglia in synaptic pruning in health and disease
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- The Endolysosomal System and Proteostasis: From Development to Degeneration
- New genetic players in late-onset Alzheimer's disease: Findings of genome-wide association studies
- Études d’association pangénomique appliquées à la recherche de nouveaux facteurs de risque génétique de la maladie d’Alzheimer
- Analysis of Reelin function in the molecular mechanisms underlying Alzheimer’s disease
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