Epigenetic Mechanisms in the Development of Type 2 Diabetes
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Summary
There is much to be learned about genome-wide epigenetic programming of health and disease before these therapies can be used in patient care, and therapeutic agents targeting epigenetic gene regulation may ultimately be used to treat T2D.
- Type
- review
- Published
- 2009-10-26
- Cited by
- 203
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W1977200537
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19519887
Keywords
Epigenetics, PDX1, Biology, GLUT4, Type 2 diabetes
References
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- Decline in Genomic DNA Methylation through Aging in a Cohort of Elderly Subjects
- Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
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- Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
- Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells.
Cited by
- Relationship between epigenetic regulation, dietary habits, and the developmental origins of health and disease theory
- Heat stress alters animal physiology and post-absorptive metabolism during pre- and postnatal development
- Prenatal Programming of Hepatic Glucose and Cholesterol Regulation in Male Rat Offspring by Chronic Intermittent Hypoxia
- Flavonoid compounds of sorghum and maize bran and their inhibitory effects against alpha - amylase
- Rising incidence and challenges of childhood diabetes. A mini review
- The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes
- Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization Guideline.
- The Effects of Telomerase Inhibition on Cellular Senescence in Fetal Guinea Pig Muscle Cells
- Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus
- Rôles du stress du réticulum endoplasmique et de l'immunité innée dans l'inhibition de la transcription du gène de l'insuline : étude du facteur de transcription ATF6 et du récepteur TLR4
- Dérégulations épigénétiques induites par la protéine fusion BRD4-NUT et caractérisation de la proteine NUT au cours de la spermatogenèse et dans les cancers
- Identification and functional studies of two novel serine phosphorylation sites of insulin receptor substrate (IRS)-2: Ser 675 and Ser 907
- Deficiency of Vitamin B12, Folate and Methionine During Preconception Period Causes Altered Immune Responses, Obesity, Insulin Resistance and Hypertension in Adult Progeny
- Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.
- Wild‐type offspring of heterozygous prolactin receptor‐null female mice have maladaptive β‐cell responses during pregnancy
- The effects of cannabinoids on insulin secretion
- Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?
- [Beyond genetics--the emerging role of epigenetics and its clinical aspects].
- Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy
- Effects of mammalian in utero heat stress on adolescent body temperature
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