Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
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Summary
These findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect and underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 1 diabetes.
- Type
- article
- Published
- 2007-06-01
- Cited by
- 2,240
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1944558458
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:206508885
Keywords
TCF7L2, Type 2 diabetes, Biology, Genome-wide association study, Genetics
References
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- Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes
- Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling.
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- Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
- Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
- Inhibition of Cyclin-dependent Kinase 5 Activity Protects Pancreatic Beta Cells from Glucotoxicity*
- Cdk5-dependent regulation of glucose-stimulated insulin secretion
- A genome-wide association study identifies novel risk loci for type 2 diabetes
- p16INK4a induces an age-dependent decline in islet regenerative potential
- Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice
- Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
- Aligning multiple genomic sequences with the threaded blockset aligner.
- GOLDsurfer: three dimensional display of linkage disequilibrium
- Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.
- Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex.
- Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Cited by
- Principal component analysis in high dimensional data: application for genomewide association studies
- Models and methods for genome -wide association studies
- The role for endoplasmic reticulum stress in diabetes mellitus.
- Die Herzinsuffizienz als komplexe genetische Erkrankung
- Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15–34 years) but not in middle-aged (40–59 years) diabetic patients
- Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening
- MODY-like diabetes associated with an apparently balanced translocation: possible involvement of MPP7 gene and cell polarity in the pathogenesis of diabetes
- Therapeutic approaches based on beta-cell mass preservation and/or regeneration.
- Mining the Human Phenome using Semantic Web Technologies: A Case Study for Type 2 Diabetes
- Understanding cardiovascular disease through the lens of genome-wide association studies.
- An overview of recent developments in genomics and associated statistical methods
- Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy
- Consistent Association of Type 2 Diabetes Risk Variants Found in Europeans in Diverse Racial and Ethnic Groups
- Two-stage testing strategies for genome-wide association studies in family-based designs.
- IGF2BP2 Genetic Variation and Type 2 Diabetes: A Global Meta-Analysis
- A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women
- Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations
- Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population
- A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye
- Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association.
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