Mammalian Rho GTPases: new insights into their functions from in vivo studies
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Summary
The recent availability of knockout mice for several members of the Rho family reveals new information about their roles in signalling to the cytoskeleton and in development.
- Type
- review
- Published
- 2008-09-01
- Cited by
- 1,936
- References
- 161
- OpenAlex
- https://openalex.org/W2071199281
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16205866
Keywords
Cell biology, GTPase, Cytokinesis, Biology, Cytoskeleton
References
- Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase
- The cofilin pathway in breast cancer invasion and metastasis
- RhoB in cancer suppression.
- A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells.
- N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
- Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases
- Reactive oxygen species in tumor progression.
- Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions1
- Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
- rac, a novel ras-related family of proteins that are botulinum toxin substrates.
- RhoB, Not RhoA, Represses the Transcription of the Transforming Growth Factor β Type II Receptor by a Mechanism Involving Activator Protein 1*
- Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths via RhoG-Mediated Mechanisms
- Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
- Rho GTPases and cell migration.
- Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes
- Growth-regulated expression of rhoG, a new member of the ras homolog gene family
- Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions1
- Genomic analysis of metastasis reveals an essential role for RhoC
- Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB.
- Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly
Cited by
- Role of Rap1 in angiogenesis and tumor invasion
- Bringing up the rear: defining the roles of the uropod
- Thromboxane A2 Receptor Activates a Rho-associated Kinase/LKB1/PTEN Pathway to Attenuate Endothelium Insulin Signaling*
- Critical roles for Rac GTPases in T-cell migration to and within lymph nodes.
- Integrin signalling adaptors: not only figurants in the cancer story
- Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome
- Cdc42 GTPase‐activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic‐rich motif
- Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.
- Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42
- RHGF-2 Is an Essential Rho-1 Specific RhoGEF that binds to the Multi-PDZ Domain Scaffold Protein MPZ-1 in Caenorhabditis elegans
- Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins
- Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.
- The faces and friends of RhoGDI2
- The Small GTPase Rif Is Dispensable for Platelet Filopodia Generation in Mice
- Structurally Governed Cell Mechanotransduction through Multiscale Modeling
- Non-muscle myosin II in disease: mechanisms and therapeutic opportunities
- Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK
- Melanocortin 1 receptor agonist protects podocytes through catalase and RhoA activation.
- NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
- Up-regulation of GTPBP4 in colorectal carcinoma is responsible for tumor metastasis.
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