Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions1

Keywords

RAC1, Chemotaxis, NADPH oxidase, Cell biology, Rac GTP-Binding Proteins

References

• The machinery of cell crawling.Ariana Eunjung — 1994
• Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions1Shijun Li, Akira Yamauchi, Christophe C. Marchal — 2002
• Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.P G Heyworth, B P Bohl, Gary Bokoch — 1994
• Conditional gene targeting in macrophages and granulocytes using LysMcre miceBjörn E. Clausen, Christoph Burkhardt, Walter Reith — 1999
• Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.Daniel Williams, W Tao, Feng‐Chun Yang — 2000
• Neutrophils from MMP‐9‐ or neutrophil elastase‐deficient mice show no defect in transendothelial migration under flow in vitroJennifer R. Allport, Yaw-Chyn Lim, J. Michael Shipley — 2002
• Cell migration: a physically integrated molecular process.Douglas A. Lauffenburger, Alan F. Horwitz — 1996
• Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).P G Heyworth, Ulla G. Knaus, Jeffrey Settleman — 1993
• Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.Mary Ann Sells, Ulla G. Knaus, Shubha Bagrodia — 1997
• Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated CellsSuranganie Dharmawardhane, Luraynne C. Sanders, Stuart S. Martin — 1997
• The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1 (*)Olivier Dorseuil, Louise Reibel, Gary Bokoch — 1996
• The p21Rac/Cdc42-activated kinases (PAKs).Ulla G. Knaus, Gary Bokoch — 1998
• Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.Andrew W. Roberts, Chaekyun Kim, Ling Zhen — 1999
• Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.Dagmar Diekmann, Arie Abo, Caroline L. Johnston — 1994
• Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background.Hiroaki Onda, A. Lueck, Peter Marks — 1999
• Regulation of neutrophil function by Rac GTPasesMary C. Dinauer — 2003
• Characterization of RAC3, a Novel Member of the Rho Family*Leena Haataja, John Groffen, Nora Heisterkamp — 1997
• Rac1 is required for the formation of three germ layers during gastrulationKazuhiro Sugihara, Norio Nakatsuji, Kenji Nakamura — 1998
• How cells process antigens.Víctor H. Engelhard — 1994
• Ras-related GTPases and the cytoskeleton.A Hall — 1992

Cited by

• Rac2 in the zebrafish (Danio rerio) with a focus on neutrophilsRachel M. Tell — 2012
• The potential role of Rac signalling and the planar cell polarity pathway in wiring of the enteric nervous systemValentina Sasselli — 2011
• Analysis of neutrophil chemotaxis.Paul A. Nuzzi, Mary A. Lokuta, Anna Huttenlocher — 2007
• Role of Rac1 in myocardial TNF-alpha expression in sepsisTing Zhang — 2011
• Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosisHeather L. Osborn-Heaford, Shubha Murthy, Linlin Gu — 2015
• Role of Integrin-linked kinase in epidermal integrity and barrier functionSamar Sayedyahossein — 2014
• Identification and Characteristics of Factors Regulating Hepatocellular Carcinoma Progression and Metastasis: A DissertationLeanne G Ahronian — 2014
• ROLE DE L'EXOENZYME S DE PSEUDOMONAS AERUGINOSA DANS LA VIRULENCE BACTERIENNE : ETUDE FONCTIONNELLE DU DOMAINE GAP ET DE SES CIBLES SUR LA REPONSE IMMUNITAIRE CHEZ DROSOPHILA MELANOGASTERAmélie Avet‐Rochex — 2005
• Charakterisierung der Funktion des switch-associated protein 70 (SWAP-70) in der N-Formylpeptid-vermittelten Signaltransduktion muriner neutrophiler GranulozytenSusann rer. nat. Piehl — 2015
• Conditional mutagenesis reveals immunological functions of widely expressed genes: activation thresholds, homeostatic mechanisms and disease models.Jürgen Roes — 2007
• Rho GTPases and regulation of hematopoietic stem cell localization.David A. Williams, Yi Zheng, José A. Cancelas — 2008
• Zoledronate and pamidronate depress neutrophil functions and survival in miceJ. W. Kuiper, Carol Forster, Chunxiang Sun — 2012
• ROS-inhibitory activity of YopE is required for full virulence of Yersinia in miceWarangkhana Songsungthong, Mary C. Higgins, Hortensia G. Rolán — 2010
• ROLE OF CXCL1 SIGNALING IN STROMA: EPITHELIUM INTERACTIONS DURING BREAST CANCER PROGRESSIONAn Zou — 2014
• Epithelial-specific knockout of the Rac1 gene leads to enamel defectsZhan Huang, Ji‐Eun Kim, Rodrigo S. Lacruz — 2011
• Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous LeukemiaJosé A. Cancelas — 2008
• The Src Family Kinases Hck and Fgr Regulate Neutrophil Responses to N-Formyl-Methionyl-Leucyl-Phenylalanine1Laura Fumagalli, Hong Zhang, Anna Baruzzi — 2007
• Pyk2 is required for neutrophil degranulation and host defense responses to bacterial infectionLynn Kamen, Joseph Schlessinger, Clifford A. Lowell — 2010
• Rac1 Mediates Collapse of Microvilli on Chemokine-Activated T LymphocytesRuchika Nijhara, Paula B. van Hennik, Michelle Gignac — 2004
• The function of Tiam1 in tumor cell biologyTomasz P. Rygiel — 2009

Related papers

• [Signal transduction by Rac small G proteins in phagocytes].Olivier Dorseuil, Gérard Gâcon — 1997
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• Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migrationClaire M. Wells, Marita J. Walmsley, Steen K.T. Ooi — 2004
• R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration, Homing, and Mobilization*Xun Shang, José A. Cancelas, Lina Li — 2011
• Rac1 and Rac2 regulate macrophage morphology but are not essential for migrationAnn P. Wheeler, Claire M. Wells, Stephen D. Smith — 2006
• The Rac Target NADPH Oxidase p67 Interacts Preferentially with Rac2 Rather Than Rac1 (*)Olivier Dorseuil, Louise Reibel, Gary Bokoch — 1996
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• Rac1 and Rac2 Are Involved in Chemotaxis and NADPH Oxidase Activity in Human MonocytesYun Tan — 2011
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